AntiHelmenthics Flashcards
Enumerate Intestinal infections (7)
[SANTA TE] Strongyloides stercoralis Ascaris lumbricoides Necator Americanus Trichuris Trichiura Ancylostoma Duodenale Trichinela Spiralis Enterobius Vermicularis
Enumerate tissue infection (2)
[wuchu doin bru?]
Wucheria bancrofti
Brugia Malayi
Broad spectrum antihelmintic
inhibits microtubules
Albendazole
MOA same as albendazole
DOC for ascaris, enterobius and trichuris infections
Mebendazole
[TAE: Tricuhiris, Ascaris, Enterobius]
depolarizing neuromuscular agent, persistent activation of nicotinic receptors
DOC for hookworm ascaris enterobius
Pyrantel Pamoate
[pyr on cigar(nicotinic), HAE!]
DOC for Ascaris and pinworm
MOA flaccid paralysis of helmith, blocks helminth response to ach
Piperazine
[flaccid paralyis when you use pipe!]
antagonistic effect with piperazine
pyrantel
DOC for onchocerca volvulus (riverblindness
MOA targets GABA receptors: paralysis of worms
Ivermectin
[riverblindness” iver}
DOC for strongyloides( threadworm)
MOA affects microtubular aggregation
AE SJS
Thiabendazole
[si tiya mananahi( threadworm)]
DOC for Filariasis
MOA immobilize microfilariae by an unknown mechanism
Diethylcarbamazine (DEC)
[Burot(filariasis) ang dick(DEC)]
Enumerate trematodes(Flukes) (4)
Chlonorchis sinensis(chines liver fluke) Schistosoma mansoni (blood fluke) schostosoma haematobium (blood fluke) Paragonimus westermani (lung fluke)
MOA: increases membrane permeability to calcium, causing marked contraction initially and then paralysis
Praziquantel
Pralysis
Enumerate Cestodes/tapeworms (5)
[DETTH by tape] Diphyllobothrium Latum Echinococcus granulosus Taenia Solium Taenia Saginata Hymenolepsis nana
MOA: Inhibits oxidative phosphorylation in mitochondira
of cestodes
[DTH by asphyxia(oxidative)]
(kulang kay sa intestines ra man)
Diphyllobothrium Latum
Taenia Saginata
Hymenolepsis nana
