CNS drugs Flashcards
drugs most important for anxiety states and insomnia
Benzodiazepines (ex Flumenazil)
drugs that facilitate GABAa action
Barbiturates (Thiopental, Phenobarbital)
rare metabolic disorder that is characterized by deficiency of the enzyme as hydroxymethylbilane synthase (also known as porphobilinogen deaminase)
acute intermittent porphyria
(baribiturates is contraindicated)
drugs that block Na channels, inhibit glutamate release
Phenytoin
AE: gingival hyperplasia, teratigenic, fetal hydantoin syndrome
Phenytoin
DOC for partial and GTC seizures, trigeminal neuralgia
Phenytoin
DOC for febrile seizures
Phenobarbital
MOA Blocks voltage gated Na channels, inc GABA concentration
Valproic acid
MOA inhibits Calcium influx, used for absence seizuresq
Ethosuximide
Fatal blood level of ethanol
400mg/DL
ethanol causes this condition
Wernicke-korsakoff syndrome
drugs with disulfiram-like reactions (3)
metronidazole, cephalosporins, procarbazine
MOA: blocks reuptake of norepi and serotonin
blocks effects of clonidine
Tricyclic antidepressants
Tricyclic antidepressant for bedwetters
imipramine
least sedating Tricyclic antidepressant
desipramine
MOA: Serotonin specific inhibitors
SSRIs
ex. Fluoxetin
SE of Monoamine oxidase inhibitors( MAOIS) + tyramin rich food causes
hypertensive crisis
SE of Monoamine oxidase inhibitors( MAOIS) + TCA
convulsions, coma
SE of Monoamine oxidase inhibitors( MAOIS) + SSRI
Serotonin syndrome (hyperthermia, muscle rigidity, myoclonus, MS changes)
DOC for tourette’s syndrome
haloperidol
DOC for intractable hiccups
chlorpromazine
DOC for antipruritic therapy
promethazine
specie strychous which chiefly contains quarternary neuromuscular blocking alkaloids
curare
