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ASS PHARMA > ANS drugs > Flashcards

ANS drugs Flashcards

1
Q

adrenergic drug:
MOA: inhibit storage in vesicles
inhibit NE and Dopamine response

A

Reserpine

cant be stored kay naa ngpa Reserve

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2
Q

MOA: inhibit release of catecholamines (2) examples

A

Guanethedine ,Brethylium

when u use adrenaline.. ma Gua imo Breth

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3
Q

MOA: stimulate sympathetic response (4) examples

A

amphetamine, metamphetamine, ephedrine, tyramine

[Amp! Phred Met Tyra]

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4
Q

Class?

MOA: Produce sympathetic response by causing an increase in the concentration of NE in the synaptic clef

A

Indirect-acting sympathomimetics

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5
Q

class?

MOA: stimulate directly adrenergic receptors

A

Direct acting sympathomimetics

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6
Q

Catecholamines is degraded by?

A

COMT

(Catechol-O-methyl transferase, found in the GI)

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7
Q

enumerate (2) common metabolite of catecholamines

A

metanephrine

Vanillyl mandelic acid (VMA)

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8
Q

Vanillyl mandelic acid (VMA) is seen in what condition?

A

Pheochromocytoma

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9
Q

enumerate (3) natural catecholamines

A

Epinephrine
Norepinephrine
Dopamine
[END]

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10
Q

decreased catecholamine concentration stimulates (?) receptors?

A

Beta receptors

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11
Q

increased catecholamine concentration stimulates (?) receptors?

A

alpha receptors

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12
Q

Endogenous source of epinephrine, what site?

A

adrenal medulla

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13
Q

Indication: ACLS, anaphylaxis, shock

A

epinephrine

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14
Q

Pivalic ester derivative of epinephrine given as opthalmic drops for glaucoma

A

Dipivefrin

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15
Q

catecholamine affinity with receptor a1 and b1 ( no effect on a2 b2)

A

norepinephrine

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16
Q

first line mgt of septic shock

A

norepinephrine

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17
Q

receptor for vasodilation of renal and splanchnic blood vessels

A

D1

[D shape like a kidney]

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18
Q

receptor for inotropic agent for shock

A

B1

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19
Q

receptor for vasoconstriction

A

a1

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20
Q

selective b1 agonist drug (1)

A

dobutamine

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21
Q

selective b2 agonist drug (rapid and short acting)

A

fenoterol albuterol salbutamol terbultaline

[FAST]

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22
Q

selective a1 agonist drug

A

phenylephrine, prophylhexedine, oxymetazoline

-ephrine, -edine, -zoline

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23
Q

selective a2 agonist drug

useful in HPN mgt

A

Clonidine, Methyldopa, Guanfancine, Guanbenz

[GMC]

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24
Q

Receptor: Suppression of release of norepinephrine (noradrenaline) by negative feedback

A

A2

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25
Q

nonselective B agonist

A

isoproterenol

26
Q

selective b2 agonist drug ( slow and low acting)

A

bambuterol, salmeterol

[BS, this is BS gi asthma na ko ang hina ng effect!]

27
Q

indication: 1. bronchial asthma, COPD 2. tocolytic

3. mgt of hyperkalemia

A

Selective b2 agonists

28
Q

SE of Selective b2 agonists (3)

A

hypokalemia
muscle tremors
tachycardia

29
Q

Clinical use: A2 agonist, local nasal decongestant

A

Clonidine

30
Q

Clinical use: A2 agonist, mgt of HPN especially among pregnant patients

A

Methyldopa

31
Q

SE: of methyldopa

A

(+)COOMB’S TEST(immune mediated hemolytic anemia)
hepatotoxicity
sedation

32
Q

drug used pre-operatively in patients with pheochromocytoma

A

Phenoxybenzamine

33
Q

clinical use:
drug selective a-1 blockers
alternative mgt of hpn

A

Phentolamine

34
Q

Phentolamine SE

A

“FIRST DOSE” phenomenon

-orthostatic hypotension

35
Q

Beta blockers known SE

A

bronchospasm

36
Q

Muscarininc receptor for ciliary muscles, glands

A

M3

37
Q

Muscarininc receptor for cardiac nerves

A

M2

38
Q

Muscarininc receptor for nerve endings

A

M1

39
Q

Nicotinic receptor for ganglia

A

N1

40
Q

Nicotinic receptor for end plate/ skeletal muscle

A

N2

41
Q

Direct acting cholinomimetics

A 
choline esters (acetylcholine, metacholine) M,N
alkaloid (pilocarpine M, muscarine M, nicotine N)
42
Q

indirect acting cholinomimetics

A

alcohol (5-15 mins)short
carbametes (30-8hrs) int (Ex. neo/physostigmine)
organophosphates (days to mos) long

43
Q

Test tool in diagnosing MG

A

Edrophoonium (aka Tensilon Test)

44
Q

Mgt of glaucoma

A

Physostigmin, Echothiopate, Demecarium
[glaucoma is in your PEDigree]

Carbachol, Pilocarpine
[Piloa ang Car kay daot kag mata]

45
Q

Antidote to Curare-like poisoning

A

Neostigmine

[neo is rare]

46
Q

Antidote to Atropine toxicity

A

Physostigmine

[tagpila ang atropine? physo ra]

47
Q

Mgt of urinary retention

A

Betanechol

48
Q

mgt of smoking addiction

A

lobeline

49
Q

Cholinergic antagonist protype

A

Atropine

50
Q

Treatment of organophosphate poisoning

A

atropine and pralidoxime

51
Q

why is atropine given with anti-diarrheal drug like diphenoxylate

A

to decrease addiction/ dependence

52
Q

nondepolarizing muscle relaxant use to provide rapid, intense short lasting muscular blockade

A

succinylcholine

53
Q

most serious complication of succinylcholine

A

hyperkalemia (with resultant cardiac arrest)

54
Q

Short acting nondepolarizing muscle relaxant

A

succinylcholine mivacurium rocuronium

[suc mi or]

55
Q

intermediate acting nondepolarizing muscle relaxant

A

vecorunium atracurium

[atrac vecor( vicar means replacement)]

56
Q

long acting nondepolarizing muscle relaxant

A

pancuronium, pipecoronium, doxacurium

[pan pipe do]

57
Q

choline esters (3)

A

bethanichol methacholine carbachol

[Beth has Meth in the Car, hint chol]

58
Q

MOA: blocks Nn receptors

A

Ganglionic blockers

59
Q

Ganglionic blocker, alternative drug of hpn urgency

A

Trimetophan

60
Q

MOA: nondepolarizing,reversible Nm blockers

A

neuromuscular blockers (curare derivatives)

ASS PHARMA (16 decks)

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