Antibiotics: Penicillin

Question 1

MOA of Penicillin

Answer 1

Interferes with the last step of bacterial cell wall synthesis (Peptidoglycan crosslinking)

Question 2

Poorly absorbed from the instestinal tract, oral doses must be very large, not effective orally

Answer 2

Penicillin G

Question 3

Acid Stable Penicillin

Answer 3

Penicillin V

Phenoxymethyl penicillin

Question 4

narrow spectrum penicillin

Answer 4

Penicillinase-resistant/ antistaphylococcal penicillins

Question 5

a prototype drog, off the market due to high incidence of intersitial nephritis

Answer 5

Methicilin

2,6 dimethoxyphenylpenicillin

Question 6

complication of methicllin

Answer 6

interstitial nephritis

Question 7

Why is Penicillin not effective against gram negative organisms

Answer 7

since gram (-) cell wall has thin peptidoglycan layer

Question 8

Most comon adverse effect of Penicillin

Answer 8

Allergy

Question 9

Penicillin that can be given to patients with renal problem

Answer 9

Nafcillin

Think: NF- no froblem

Question 10

best absorbed isoxazolyl penicillin

Answer 10

dicloxacillin

Question 11

Penicillin with antibacterial spectrum similar to that of pen G but are more effective against gram negative bacilli

Answer 11

Aminopenicillins

Question 12

Aminopenicillin more frequently administered parenterally, poor GI absorption

Answer 12

Ampicillin

Question 13

Aminopenicillin better GI absorption than Ampicillin

Answer 13

Amoxicillin

Question 14

Prodrugs of ampicillin

Answer 14

Bacampicillin, Hetacillin, Cyclicillin

camp ta cycle

Question 15

If patient is allergic to penicilin we may give what?

Answer 15

Erythromycin

Question 16

Antipseudomonal Penicillins

Answer 16

Carboxypenicillins( ticarcillin)
Ureidopenicillins (piperacillin- most potent)
[think: ligsan car ang psedumonas, papaak sa ido named piper]

Question 17

structurally related to the beta-lactam ring of penicilin.

binds to inactivate beta-lactamases

Answer 17

Clavulanic acid, sulbactactam, tazobactam