Protein synthesis inhibitors Flashcards
inhibit protein synthesis at the 30s ribosomal unit, highly polar, derived from streptomyces or from microminispora,
Aminoglycosides
only topical/oral aminoglycoside
neomycin
adverse reaction of aminoglycosides
nephrotoxicity and ototoxicity
aminoglycosides used as as prophylaxis for surgery
netilmycin
[ne tiil- putlon-surgery]
Broadest spectrum antibiotic, against Spirochetes, Mycoplasma, Rickettsia, gram(+,-) chlamydia , inhibit protein synthesis at the 30s
Tetracycline
[SMaRT Chlam stays away from the fish(tetra)]
Tetracycline Adverse reaction
discoloration and hypoplasia of the teeth
Tetracycline known to cause phototoxicity
demeclocycline
[photo:papicture? di mi close]
Tetracycline known to cause vestibular problems
minocycline
[mino: INOM- hubog- vestibular hearing and balance]
activity on 50s, actvity resembles pen G, but also effective against mycoplasma, chlamydia, campylobacter, legionela,
Macrolide
Macrolide alternative to penicillin
Erythromycin
Preferred drug for Legionnaire’s disease, mycoplasma, campylobacterm chlamydia, diptheria, pertussis
Erythromycin
[LegionER]
Erthromycin is inactivated by gastric acid? T or F?
true
Esters of Erthromycin
stearate, estolate. ethylsuccinate
[(eS)eStearate (eR) eS, eT)
Use with Omeprazole or Lanzoprazole for H. Pylori eradication
Clarithromycin
for nongonoccocal urethritis, chlamydia, LRTI, PID, pharyngitis, legionaires,
nog administered with food
Azithromycin
