Sympatholytics Flashcards
non selective alpha antagonist struture
betahaloalkylamine
what kind of modification do alkylamines make
covalent nonreversible
dose response curve reversible vs irreversible
reversible is competitive, shift right
nonreversible is noncompetitive, shift down and decrease available receptors
non selective alpha antagonists action
more NE release, increased heart rate
alpha 1 antagonists structure
quinazolines, -azosin
alpha 1 antagonists secretion
in bile mostly
beta blockers cardiovascular indications
hypertension, angina, cardiac arrhythmia, congestive heart failure, post heart attack
beta blockers active stereochem
s
-olol
beta blocker
propanolol excretion and halflife
first pass metabolism, excreted before urine, short half-life 3 hours
nadolol metabolism if longer half life
unchanged in urine
how will beta blockers affect pupil size?
no effect, thats alpha
partial agonists benefits
less likely to cause bradycardia, good for patients with shit cardiac reserve
what do partial agonists have?
intrinsic sympathomimetic activity
-olol taper dose
withdrawal syndrome and rebound hypertension
