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PHRM 825 > ANS Drugs > Flashcards

ANS Drugs Flashcards

1
Q

pilocarpine

A

m3 agonist
promote sweating, urination, salivation, glaucoma (outflow humor)

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2
Q

methacholine

A

muscarinic agonist
provocative test for hyperactive airways

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3
Q

carbachol

A

muscarinic agonist
ocular (surgery, glaucoma)

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4
Q

bethanechol

A

muscarinic agonist
GI stimulation, urinary retention

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5
Q

varenicline (Chantix)

A

nicotinic partial agonist
smoking cessation
boxed warning: depression/suicide

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6
Q

bupropion (Wellbutrin)

A

used for depression or smoking cessation
less effective than varenicline

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7
Q

edrophonium

A

AChE inhibitor
reversible and noncovalent
treatment of Myasthenia Gravis
short acting

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8
Q

pyridostigmine

A

AChE inhibitor
reversible and covalent
treatment of Myasthenia Gravis
pretreatment nerve gas

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9
Q

neostigmine

A

AChE inhibitor
reversible and covalent
treatment Myasthenia Gravis
post op urinary retention

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10
Q

echothiophate

A

AChE inhibitor
irreversible and covalent
treatment glaucoma

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11
Q

sarin

A

AChE inhibitor
irreversible and covalent
nerve gas

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12
Q

2-PAM

A

AChE inhibitor ANTIDOTE
treats aging due to organophosphate toxicity
combined with atropine

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13
Q

atropine

A

muscarinic antagonist with 2-PAM

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14
Q

donepezil

A

AChE inhibitor
symptoms of Alzhemiers
does not slow progression

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15
Q

rivastigmine

A

AChE inhibitor
reversible covalent
symptoms of alzheimers
loses effectiveness as disease progresses

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16
Q

donepezil

A

AChE inhibitor
reversible noncovalent
symptoms of Alzheimers
does not slow progression of disease

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17
Q

galantamine

A

AChE inhibitor
reversible competitive
symtoms alzheimers
loses effectiveness as disease progresses

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18
Q

memantamine

A

NMDA antagonist
treatment alzheimers
may slow progression of disease

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19
Q

physostigmine

A

AChE inhibitor
antimuscarinic poisioning

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20
Q

atropine

A

muscarinic antagonist
GI/urinary or motion sickness
M nonselective

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21
Q

scopolamine

A

muscarinic antagonist
treatment of motion sickness

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22
Q

homatropine

A

muscarinic antagonist
short acting
optical dilation

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23
Q

tropicamide

A

muscarinic antagonist
short acting
optical dilation

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24
Q

benztropine

A

muscarinic antagonist
used for Parkinsons disease
sedative activity
conjunct with LDOPA

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25
trihexyphenidyl
muscarinic antagonist used for Parkinsons disease sedative activity
26
ipratropium (atrovent)
muscarinic antagonist (M3) COPD occasionally asthma reduce bronchoconstriction
27
combivent/duoneb
ipratropium/albuterol
28
tiotropium (Spiriva)
longer acting analog of ipratropium
29
glycopyrrolate
antimuscarinic quartenary amine pre op to reduce secretions, gastric disorders
30
tolterodine
antimuscarinic tertiary amine overactive bladder
31
turbocarine
neuromuscular blockade skeletal muscle relaxation during anesthesia
32
succinylcholine
neuromuscular blocker depolarizing skeletal muscle relaxation during anesthesia
33
botulinum toxin
indirect anticholinergic inhibit release of ACh muscle spasms, sweating, anal fissure
34
hexamethonium
ganglionic nicotinic antagonist blocks all SNS and PSNS activity originally used for hypertension
35
norepinephrine
alpha and beta 1 agonist increase blood pressure increase heart rate
36
epinephrine
alpha and beta agonist increase blood pressure, heart rate decrease blood pressure (low conc) used in anaphylaxis/cardiac arrest
37
dopamine
d1 b1 and a1 agonist used for shock, congestive heart failure
38
fenoldopam
selective d1 agonist, severe hypertension in hospitalized patients
39
dobutamine
mixed alpha 1 beta 1 agonist acute heart failure, shock lab stress test
40
phenylephrine
alpha 1 agonist nasal decongestant, pupil dilation not very effective
41
-azoline drugs
alpha 1 agonist nasal and opthalmic decongestants
42
clonidine
alpha 2 agonist decrease SNS activity hypertension opioid withdrawal ADHD
43
guanabenz
alpha 2 agonist hypertension ADHD
44
guanfacine
alpha 2 agonist hypertension ADHD
45
methyldopa
alpha 2 agonist prodrug hypertension during pregnancy
46
brimonidine
alpha 2 agonist glaucoma inhibits production and stimulates outflow
47
tizanidine
alpha 2 agonist muscle spasticity
48
isoproterenol
nonselective beta agonist asthma, COPD, cardiostimulant
49
-erol drugs
beta 2 agonists asthma, COPD
50
terbutaline
beta 2 agonist asthma, COPD, premature labor
51
albuterol
beta 2 agonist asthma, COPD shorter acting
52
formoterol and salmeterol
beta 2 agonist asthma, COPD long term (not for acute asthma)
53
mirabegron (Myrbetriq)
beta 3 agonist overactive bladder slow onset (8 weeks)
54
amphetamine/methamphetamine
indirect sympathomimetic narcolepsy, ADHD
55
phentermine/topiramate
indirect sympathomimetic weight loss, diabetes
56
ephedrine
indirect and direct beta agonist (stereochem) weight loss, muscle strength DO NOT TAKE W MAOI
57
pseudoephedrine
indirect sympathomimetic nasal decongestant DO NOT TAKE W MAOI
58
cocaine
indirect sympathomimetic NET inhibitor local anesthetic
59
methylphenidate
indirect sympathomimetic NET inhibitor/DAT inhibitor ADHD, narcolepsy
60
atomoxetine
indirect sympathomimetic NET inhibitor ADHD non stim, black box suicide
61
phenoxybenzamine
non selective alpha antagonist pheochromocytoma, hypertensive crisis covalent modification
62
phentolamine
nonselective alpha antagonist pheochromocytoma, hypertensive crisis, male impotence noncovalent
63
prazosin
alpha 1 antagonist hypertension reynauds syndrome benign prostatic hyperplasia
64
-azosin drugs
alpha 1 antagonists
65
tamsulosin
alpha 1 antagonist benign prostatic hyperplasia increase urination
66
-olol ending
beta blocker
67
propanolol
non selective beta antagonist hypertension, angina, arrhythmias, ichemic heart disease, migraine prophylaxis TAPER DOSE
68
nadolol
nonselective beta antagonist hypertension, angina, migraine
69
timolol
nonselective beta antagonist glaucoma, hypertension, angina, migraine decrease production of humor
70
pindolol
nonselective beta antagonist partial agonist hypertension, angina, migraine
71
carteolol
nonselective beta antagonist partial agonist hypertension, glaucoma
72
metoprolol
beta 1 antagonist cardioselective hypertension, angina, arrhythmias, congestive heart failure less bronchoconstriction taper dose
73
atenolol
beta 1 antagonist cardioselective hypertension, angina
74
esmolol
beta 1 antagonist tachycardia, a fib, periop surgery rapid hydrolysis (esterase breakdown)
75
nebivolol
beta 1 antagonist hypertension vasodilation due to NO production
76
labetalol
mixed adrengeric antagonist non selective beta, alpha 1 hypertension, hypertensive crisis beta blocking prevents reflex tachycardia
77
carvedilol
mixed adrengeric antagonist non selective beta, alpha 1 hypertension, congestive heart failure prevents reflex tachycardia
78
metyrosine
indirect sympatholytic management of pheochromocytoma depletes catecholamines
79
bretylium tosylate
indirect sympatholytic antiarrhythmic prevent release NE
80
reserpine
indirect sympatholytic VMAT inhibitor depletes NE bad side effects

PHRM 825 (24 decks)

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