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PHRM 825 > ANS Drugs > Flashcards

ANS Drugs Flashcards

1
Q

pilocarpine

A

m3 agonist
promote sweating, urination, salivation, glaucoma (outflow humor)

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2
Q

methacholine

A

muscarinic agonist
provocative test for hyperactive airways

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3
Q

carbachol

A

muscarinic agonist
ocular (surgery, glaucoma)

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4
Q

bethanechol

A

muscarinic agonist
GI stimulation, urinary retention

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5
Q

varenicline (Chantix)

A

nicotinic partial agonist
smoking cessation
boxed warning: depression/suicide

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6
Q

bupropion (Wellbutrin)

A

used for depression or smoking cessation
less effective than varenicline

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7
Q

edrophonium

A

AChE inhibitor
reversible and noncovalent
treatment of Myasthenia Gravis
short acting

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8
Q

pyridostigmine

A

AChE inhibitor
reversible and covalent
treatment of Myasthenia Gravis
pretreatment nerve gas

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9
Q

neostigmine

A

AChE inhibitor
reversible and covalent
treatment Myasthenia Gravis
post op urinary retention

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10
Q

echothiophate

A

AChE inhibitor
irreversible and covalent
treatment glaucoma

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11
Q

sarin

A

AChE inhibitor
irreversible and covalent
nerve gas

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12
Q

2-PAM

A

AChE inhibitor ANTIDOTE
treats aging due to organophosphate toxicity
combined with atropine

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13
Q

atropine

A

muscarinic antagonist with 2-PAM

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14
Q

donepezil

A

AChE inhibitor
symptoms of Alzhemiers
does not slow progression

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15
Q

rivastigmine

A

AChE inhibitor
reversible covalent
symptoms of alzheimers
loses effectiveness as disease progresses

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16
Q

donepezil

A

AChE inhibitor
reversible noncovalent
symptoms of Alzheimers
does not slow progression of disease

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17
Q

galantamine

A

AChE inhibitor
reversible competitive
symtoms alzheimers
loses effectiveness as disease progresses

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18
Q

memantamine

A

NMDA antagonist
treatment alzheimers
may slow progression of disease

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19
Q

physostigmine

A

AChE inhibitor
antimuscarinic poisioning

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20
Q

atropine

A

muscarinic antagonist
GI/urinary or motion sickness
M nonselective

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21
Q

scopolamine

A

muscarinic antagonist
treatment of motion sickness

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22
Q

homatropine

A

muscarinic antagonist
short acting
optical dilation

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23
Q

tropicamide

A

muscarinic antagonist
short acting
optical dilation

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24
Q

benztropine

A

muscarinic antagonist
used for Parkinsons disease
sedative activity
conjunct with LDOPA

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25
Q

trihexyphenidyl

A

muscarinic antagonist
used for Parkinsons disease
sedative activity

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26
Q

ipratropium (atrovent)

A

muscarinic antagonist (M3)
COPD occasionally asthma
reduce bronchoconstriction

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27
Q

combivent/duoneb

A

ipratropium/albuterol

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28
Q

tiotropium (Spiriva)

A

longer acting analog of ipratropium

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29
Q

glycopyrrolate

A

antimuscarinic quartenary amine
pre op to reduce secretions, gastric disorders

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30
Q

tolterodine

A

antimuscarinic tertiary amine
overactive bladder

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31
Q

turbocarine

A

neuromuscular blockade
skeletal muscle relaxation during anesthesia

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32
Q

succinylcholine

A

neuromuscular blocker depolarizing
skeletal muscle relaxation during anesthesia

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33
Q

botulinum toxin

A

indirect anticholinergic
inhibit release of ACh
muscle spasms, sweating, anal fissure

34
Q

hexamethonium

A

ganglionic nicotinic antagonist
blocks all SNS and PSNS activity
originally used for hypertension

35
Q

norepinephrine

A

alpha and beta 1 agonist
increase blood pressure
increase heart rate

36
Q

epinephrine

A

alpha and beta agonist
increase blood pressure, heart rate
decrease blood pressure (low conc)
used in anaphylaxis/cardiac arrest

37
Q

dopamine

A

d1 b1 and a1 agonist
used for shock, congestive heart failure

38
Q

fenoldopam

A

selective d1 agonist, severe hypertension in hospitalized patients

39
Q

dobutamine

A

mixed alpha 1 beta 1 agonist
acute heart failure, shock
lab stress test

40
Q

phenylephrine

A

alpha 1 agonist
nasal decongestant, pupil dilation
not very effective

41
Q

-azoline drugs

A

alpha 1 agonist
nasal and opthalmic decongestants

42
Q

clonidine

A

alpha 2 agonist
decrease SNS activity
hypertension
opioid withdrawal
ADHD

43
Q

guanabenz

A

alpha 2 agonist
hypertension
ADHD

44
Q

guanfacine

A

alpha 2 agonist
hypertension
ADHD

45
Q

methyldopa

A

alpha 2 agonist
prodrug
hypertension during pregnancy

46
Q

brimonidine

A

alpha 2 agonist
glaucoma
inhibits production and stimulates outflow

47
Q

tizanidine

A

alpha 2 agonist
muscle spasticity

48
Q

isoproterenol

A

nonselective beta agonist
asthma, COPD, cardiostimulant

49
Q

-erol drugs

A

beta 2 agonists
asthma, COPD

50
Q

terbutaline

A

beta 2 agonist
asthma, COPD, premature labor

51
Q

albuterol

A

beta 2 agonist
asthma, COPD
shorter acting

52
Q

formoterol and salmeterol

A

beta 2 agonist
asthma, COPD
long term (not for acute asthma)

53
Q

mirabegron (Myrbetriq)

A

beta 3 agonist
overactive bladder
slow onset (8 weeks)

54
Q

amphetamine/methamphetamine

A

indirect sympathomimetic
narcolepsy, ADHD

55
Q

phentermine/topiramate

A

indirect sympathomimetic
weight loss, diabetes

56
Q

ephedrine

A

indirect and direct beta agonist (stereochem)
weight loss, muscle strength
DO NOT TAKE W MAOI

57
Q

pseudoephedrine

A

indirect sympathomimetic
nasal decongestant
DO NOT TAKE W MAOI

58
Q

cocaine

A

indirect sympathomimetic
NET inhibitor
local anesthetic

59
Q

methylphenidate

A

indirect sympathomimetic
NET inhibitor/DAT inhibitor
ADHD, narcolepsy

60
Q

atomoxetine

A

indirect sympathomimetic
NET inhibitor
ADHD
non stim, black box suicide

61
Q

phenoxybenzamine

A

non selective alpha antagonist
pheochromocytoma, hypertensive crisis
covalent modification

62
Q

phentolamine

A

nonselective alpha antagonist
pheochromocytoma, hypertensive crisis, male impotence
noncovalent

63
Q

prazosin

A

alpha 1 antagonist
hypertension
reynauds syndrome
benign prostatic hyperplasia

64
Q

-azosin drugs

A

alpha 1 antagonists

65
Q

tamsulosin

A

alpha 1 antagonist
benign prostatic hyperplasia
increase urination

66
Q

-olol ending

A

beta blocker

67
Q

propanolol

A

non selective beta antagonist
hypertension, angina, arrhythmias, ichemic heart disease, migraine prophylaxis
TAPER DOSE

68
Q

nadolol

A

nonselective beta antagonist
hypertension, angina, migraine

69
Q

timolol

A

nonselective beta antagonist
glaucoma, hypertension, angina, migraine
decrease production of humor

70
Q

pindolol

A

nonselective beta antagonist
partial agonist
hypertension, angina, migraine

71
Q

carteolol

A

nonselective beta antagonist
partial agonist
hypertension, glaucoma

72
Q

metoprolol

A

beta 1 antagonist
cardioselective
hypertension, angina, arrhythmias, congestive heart failure
less bronchoconstriction
taper dose

73
Q

atenolol

A

beta 1 antagonist
cardioselective
hypertension, angina

74
Q

esmolol

A

beta 1 antagonist
tachycardia, a fib, periop surgery
rapid hydrolysis (esterase breakdown)

75
Q

nebivolol

A

beta 1 antagonist
hypertension
vasodilation due to NO production

76
Q

labetalol

A

mixed adrengeric antagonist
non selective beta, alpha 1
hypertension, hypertensive crisis
beta blocking prevents reflex tachycardia

77
Q

carvedilol

A

mixed adrengeric antagonist
non selective beta, alpha 1
hypertension, congestive heart failure
prevents reflex tachycardia

78
Q

metyrosine

A

indirect sympatholytic
management of pheochromocytoma
depletes catecholamines

79
Q

bretylium tosylate

A

indirect sympatholytic
antiarrhythmic
prevent release NE

80
Q

reserpine

A

indirect sympatholytic
VMAT inhibitor
depletes NE
bad side effects

PHRM 825 (24 decks)

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