Steroids Flashcards

1
Q

name the carbons

A
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2
Q
A

cortisol

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3
Q
A

aldosterone

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4
Q
A

progesterone

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5
Q
A

testosterone

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6
Q
A

17 beta estradiol

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7
Q

progesterone

A

female menstrual cycle, pregnancy, embryogenesis

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8
Q

17 beta estradiol

A

estrogen, female hormone

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9
Q

testosterone

A

androgen, male hormone

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10
Q

cortisol

A

glucocorticoid, anti-stress hormone, anti-inflammation

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11
Q

aldosterone

A

mineralocorticoids, regulator Na uptake in kidney, raises blood volume and blood pressure

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12
Q

17 alpha hydroxylase deficiency

A

adrenal hyperplasia (5%), overproduction mineralcorticoids, sex hormone deficiency, hyperaldosteronism

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13
Q

21 hydroxylase deficiency

A

adrenal hyperplasia (95%), hirsutism, early epiphyseal closure, hypoaldosteronism

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14
Q

aminoglutethimide (action/use)

A

inhibits aromatase and P450scc
used to block steroid production in some hormone-dependent tumors (breast, prostate)

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15
Q
A

aminoglutethimide

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16
Q

ketoconazole (action/use)

A

antifungal at lower concentrations by blocking the synthesis of estrogen, inhibits P450scc, 17 alpha-hydroxylase, 11 beta-hydroxylase
used for hyperglucocorticoid states (Cushing’s Syndrome)
may cause toxic side effects

17
Q
A

ketoconazole