Corticosteroids Flashcards
glucocorticoids
stress hormones
increase glucose concentrations
anti-inflammatory effects
mineralocorticoids
Na+ retention
increase blood volume
increase blood pressure
cortisol (hydrocortisone)
binds glucocorticoid receptor
long term persistent response
inhibit inflammatory processes
increase energy levels
2 mechanisms of action glucocorticoids
anti inflammatory and immunosupression
glucocorticoid effect in liver
increase gluconeogenesis and glycogen storage
glucocorticoid effect in muscle
promote protein degradation
decrease protein synthesis
decrease sensitivity to insulin
glucocorticoid effect in adipose tissue
promote lipolysis, decrease sensitivity to insulin
glucocorticoid effect on immune system
block cytokine synthesis and inhibit production eicosanoids
immunosuppression and anti-inflammation
Addisons Disease
destruction of the cortex by tuberculosis or atrophy, decreased cortisol and aldosterone production, increased ACTH and CRH
addisons disease symptoms (adrenal insufficiency)
weakness, anorexia, low blood pressure, depression
cessation of long term glucocorticoid therapy can lead to ____
addisonian symptoms
Cushing’s Disease (hyperadrenalism)
tumors in adrenal cortex (adrenal)
pituitary carcinoma (increased ACTH)
non pituitary carcinoma (increased ectopic ACTH)
cushings disease symptoms
increased protein catabolism (brusing, delayed wound healing, muscle wasting)
osteoporosis
infections
long term use of glucocorticoids can lead to ___
cushings symptoms
use of corticosteroids
allerigic reactions, inflammation, autoimmune disease, asthma, immunosuppressive