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PHRM 825 > Anticholinergics > Flashcards

Anticholinergics Flashcards

1
Q

atropine

A

oldest and most well known antimuscarinic at M1-3 receptors

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2
Q

effect antimuscarinic on exocrine glands

A

decreased sweating / secretions

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3
Q

effect antimuscarinic eye

A

pupil dilation

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4
Q

effect antimuscarinic cardiovascular

A

increase heart rate

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5
Q

effect antimuscarinic respiraotry

A

block vasoconstriction, COPD / asthma

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6
Q

effect antimuscarinic bladder

A

decreased tone and constricted sphincter, reduce need to pee

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7
Q

effect antimuscarinic GI smooth muscle

A

decreased motility and tone, helps reduce need to poo

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8
Q

effect antimuscarinic CNS

A

block of all muscarinic, motion sickness

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9
Q

atropine problem

A

lack of selectivity

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10
Q

antimuscarinic strucutre

A

tertiary and quartenary amines

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11
Q

tertiary amines have good access to what

A

CNS

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12
Q

scopolamine

A

treatment motionsickness
lipophillic, better CNS
dry mouth, sedation

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13
Q

short acting tertiary amines

A

homatropine and tropicamide, used in optical applications

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14
Q

benztropine and trihexyphenidyl

A

tertiary amines for parkinsons

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15
Q

ipratopium

A

m3 antagonist
copd/asthma
reduce bronchoconstriction

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16
Q

tolterodine

A

OAB

17
Q

-fenacin drugs are used to treat:

A

overactive bladder

18
Q

antimuscarinic poisioning treatment

A

change medecine / dose
sodium bicarb / benzodiazepines
physostigmine, AChE inhibitor

19
Q

what do neuromuscular blocking agents look like

A

acetylcholine!
succinylcholine is dimer of ACh
turbocarine is like a big circcle

20
Q

non depolarizing blockade

A

turbocarine, competitive antagonist

21
Q

depolarizing blockade

A

initially an agonist then persistent depolarization of blockade so resistant to ACh
succinylcholine

22
Q

indirect antagonist

A

botox, inhibits ACh release

23
Q

ganglionic receptor antagonist

A

hexamethonium
blocks all SNS and PSNS activity

PHRM 825 (24 decks)

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