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PHRM 825 > Pituitary Hormones > Flashcards

Pituitary Hormones Flashcards

1
Q

hypothalamus hormones

A

GHRH, SST, TRH, CRH, GnRH

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2
Q

anterior pituitary hormones

A

GH, TSH, ACTH, FSH, LH

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3
Q

GH

A

growth hormone, prolactin, increase lean body mass, decrease fat, mediated by producing IGF-1

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4
Q
A

growth hormone

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5
Q

what is mecasermin used for

A

recombinant IGF-1, used in deficiency, hypoglycemia may occur

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6
Q

acromegaly

A

abnormal growth of cartilage, bone, other organs

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7
Q

GH pituitary adenomas

A

pituitary tumors, can be treated with GH antagonists

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8
Q

somatostatin analogs

A

octreotide, lanreotide

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9
Q

GH antagonist

A

pegvisomant

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10
Q
A

FSH

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11
Q
A

hCG

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12
Q

growth hormone half life

A

short, 20-25 min

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13
Q

FSH, LH, hCG

A

10-40 hours

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14
Q

lutropin alpha

A

recombinant LH, used for infertile women

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15
Q

hCG

A

extracted from urine pregnant women

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16
Q

male infertility treatment

A

requires LH and FSH, injection of hCG then hMG

17
Q

adverse effects ovulation induction

A

ovarian enlargemnt, multiple pregnancy

18
Q

-relin

A

analogs of GnRH

19
Q

GnRH use (pulsatile)

A

infertility in male and female, must be pulsatile

20
Q

GnRH use supression

A

ovarian hyperstimulation, endometriosis, prostate cancer, central precoious puberty

21
Q

-elix

A

GnRH antagonists

22
Q

GnRH antagonist uses

A

controleled ovarian hyperstimulation, advanced prostate cancer

23
Q
24
Q

what is prolactin responsible for

25
Q

what inhibits prolactin

26
Q

hyperprolactinemia

A

too much prolactin, inhibit GnRH release
amenhorrea in women, loss libido and infertility in men
treated with dopamine agonists

27
Q

posterior pituitary hormones

A

vasopressin and oxytocin

28
Q

vasopressin physiological actions

A

reduce urine volume
increase blood volume
raise blood pressure

29
Q

V1 receptor

A

increase Ca
increase blood pressure

30
Q

V2 receptor

A

increase cAMP
incease water permeability

31
Q

desmopressin is selective for ____ receptor

32
Q

clinical uses vasopressin

A

pituitary diabetes insipidus
nocturnal enuresis
coagulopathy

33
Q

adverse effects vasopressin

A

water intoxification
abdominal cramping
allergic reaction
(dont use vasopressin if cardiovascular disease)

34
Q

oxytocin clinical uses

A

induction labor
control uterine hemmorhage
milk ejection

35
Q

adverse effects oxytocin

A

excessive stim of uterine contraction before delivery
activation of vasopressin receptors
contraindications: fetal stress, weird fetal position

36
Q

adverse effects oxytocin

A

excessive stim of uterine contraction before delivery
activation of vasopressin receptors
contraindications: fetal stress, weird fetal position

PHRM 825 (24 decks)

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