Pituitary Hormones

Question 1

hypothalamus hormones

Answer 1

GHRH, SST, TRH, CRH, GnRH

Question 2

anterior pituitary hormones

Answer 2

GH, TSH, ACTH, FSH, LH

Question 3

GH

Answer 3

growth hormone, prolactin, increase lean body mass, decrease fat, mediated by producing IGF-1

Question 4

Answer 4

growth hormone

Question 5

what is mecasermin used for

Answer 5

recombinant IGF-1, used in deficiency, hypoglycemia may occur

Question 6

acromegaly

Answer 6

abnormal growth of cartilage, bone, other organs

Question 7

GH pituitary adenomas

Answer 7

pituitary tumors, can be treated with GH antagonists

Question 8

somatostatin analogs

Answer 8

octreotide, lanreotide

Question 9

GH antagonist

Answer 9

pegvisomant

Question 10

Answer 10

FSH

Question 11

Answer 11

hCG

Question 12

growth hormone half life

Answer 12

short, 20-25 min

Question 13

FSH, LH, hCG

Answer 13

10-40 hours

Question 14

lutropin alpha

Answer 14

recombinant LH, used for infertile women

Question 15

hCG

Answer 15

extracted from urine pregnant women

Question 16

male infertility treatment

Answer 16

requires LH and FSH, injection of hCG then hMG

Question 17

adverse effects ovulation induction

Answer 17

ovarian enlargemnt, multiple pregnancy

Question 18

-relin

Answer 18

analogs of GnRH

Question 19

GnRH use (pulsatile)

Answer 19

infertility in male and female, must be pulsatile

Question 20

GnRH use supression

Answer 20

ovarian hyperstimulation, endometriosis, prostate cancer, central precoious puberty

Question 21

-elix

Answer 21

GnRH antagonists

Question 22

GnRH antagonist uses

Answer 22

controleled ovarian hyperstimulation, advanced prostate cancer

Question 23

Answer 23

prolactin

Question 24

what is prolactin responsible for

Answer 24

lactation

Question 25

what inhibits prolactin

Answer 25

dopamine

Question 26

hyperprolactinemia

Answer 26

too much prolactin, inhibit GnRH release amenhorrea in women, loss libido and infertility in men treated with dopamine agonists

Question 27

posterior pituitary hormones

Answer 27

vasopressin and oxytocin

Question 28

vasopressin physiological actions

Answer 28

reduce urine volume increase blood volume raise blood pressure

Question 29

V1 receptor

Answer 29

increase Ca increase blood pressure

Question 30

V2 receptor

Answer 30

increase cAMP incease water permeability

Question 31

desmopressin is selective for ____ receptor

Answer 31

V2

Question 32

clinical uses vasopressin

Answer 32

pituitary diabetes insipidus nocturnal enuresis coagulopathy

Question 33

adverse effects vasopressin

Answer 33

water intoxification abdominal cramping allergic reaction (dont use vasopressin if cardiovascular disease)

Question 34

oxytocin clinical uses

Answer 34

induction labor control uterine hemmorhage milk ejection

Question 35

adverse effects oxytocin

Answer 35

excessive stim of uterine contraction before delivery activation of vasopressin receptors contraindications: fetal stress, weird fetal position

Question 36

adverse effects oxytocin

Answer 36

excessive stim of uterine contraction before delivery activation of vasopressin receptors contraindications: fetal stress, weird fetal position