Supportive care facts

Question 1

TLS criteria

Answer 1

2 of:
Uric acid > 8
Ca < 7
K >6
P > 4.5

+ 1 Clinical:
AKI
Arrythmia
Seizure
Death

Question 2

Maintaining urine output in TLS

Answer 2

Fluids to 2ml/kg/h
add fusid if urine output not met

Question 3

Rasburicase indication in TLS

Answer 3

Moderate- High tumor burden with high lysis potential
Laboratory TLS

Question 4

Allopurinol indication in TLS prevention

Answer 4

Medium tumor burden +
Preexisting nephropathy/
Dehydration/
Acidosis/
Hypotension/
Nephrotoxin exposure/

Question 5

EPO in cancer related anemia

Answer 5

aim of Hb of 10 g%
treat in non-curative cancers

Question 6

Tx of SVC syndrome

Answer 6

If diagnosis is certain Tx with steroids
If not certain diagnosis is lymphoma endovascular stent or endovascular thrmobolysis (If thrombus present) may be needed

Question 7

Tx of leukostasis

Answer 7

Induction Tx
If not possible immediately - HU or PEX

Question 8

GCSF indication in CHOP Tx pts

Answer 8

Age > 65
Prior cytopenia
High ECOG
Severe comorbidities