AL amyloidosis facts Flashcards
1
Q
% of lambda in AL amyloidosis
A
80%
2
Q
presence of t(11:14) on AL amyloidosis
A
40-60%
associated with poor response and poor OS
3
Q
Standard of care 1st line Tx in AL amyloidosis
A
ANDROMEDA
DVCd for 6 cycles
followed by Dara main up o 24 months
vs VCd X6
80% VGPR
CR 50% vs 14%
4
Q
timing of ASCT in AL amyloidosis
A
CR2
usually deferred until relapse and not in CR1
5
Q
AL amyloidosis goals of Tx
A
VGPR after 2 cycles
6
Q
Tx of MRD positivity in AL amyloidosis
A
in fit pts in CR but without organ response- MRD can guide the need for further TX
7
Q
IgM-related AL amyloidosis
A
6-10% of AL amyloidosis
most are LPL and not PC
Tx is based on the clone
