HL facts

Question 1

Pediatric Infections relationship to HL incidence

Answer 1

MMRV infections at childhood may be protective of HL

Question 2

B symp at diagnosis of HL

Answer 2

33%

Question 3

Nodular lymphocyte predominant HL

Answer 3

WHO- same classification
ICC- removed it from HL, now called- “Nodular lymphocyte predominant B cell lymphoma”

Question 4

Prognostic cytogenetic factors in HL

Answer 4

Amplification of 9p24.1 is correlated with advanced stage and shorter PFS
Respondes to PD1

Question 5

IPS

Answer 5

Age >45
Male

Stage IV

Albumin < 4
Hb < 10.5
WBC > 15
Lymphocyte < 600

Question 6

Early favorable HL Tx

Answer 6

H10
2 ABVD
PETCT
Negative + 20 Gy radiation
Positive - 2 eBECOPP + RT

Question 7

Unfavorable HL Tx

Answer 7

2 + 2 ABVD + 30 Gy radiation

Question 8

Deauville score

Answer 8

2- below mediastinum
3- below liver

Question 9

BrECADD vs escalated BEACOPP in HL

Answer 9

HD21 trial
pts under 60 YO
Better PFS with less toxicity
No OS

Question 10

Tx of frail pts of HL

Answer 10

Bv-Nivo
Bv-decarbazine

Question 11

Tx of unfit pts with advanced HL

Answer 11

Sequential Bv-AVD

Question 12

2xeBECOPP+2xABVD vs 4xABVD in early unfavoravble HL

Answer 12

Better PFS but not OS
More toxicity

Question 13

Tx of PET2 positive early favorable HL after 2xABVD

Answer 13

2xeBECOPP+RT