BL facts Flashcards
1
Q
Subtypes of BL
A
Endemic- jaw (EBV)
Sporadic- abdominal
Immunodeficiency associated- HIV
2
Q
Sporadic BL
A
Mainly pediatric
Not related to EBV
Extra nodal involvement
CNS (leptomeningeal) involvement is common- 20%
3
Q
M:F of BL
A
2:1
4
Q
Immunodeficiency associated BL
A
Nodal
not related to CD4 counts!
5
Q
Immunophenotype BL
A
CD20, CD10, BCL6, CD79a, HLADR, CD45 -positive
CD5, BCL2, TdT, CD23- negative
6
Q
Pathology of BL
A
Intermediate size uniform cells
Basophilic cytoplasm
Prominent vacuoles
Round nuclei
7
Q
OS of BL
A
5 year 80%
8
Q
Tx options for BL
A
DA-EPOCH-R
R-CODOX-M
GMALL
9
Q
BL-IPI
A
Age > 40
ECOG > 1
CNS involvement
LDH
10
Q
Tx of low risk BL
A
2+1 DA-EPOCH-R
11
Q
Tx of high risk BL
A
6 DA-EPOCH-R
with IT MTX
12
Q
CNS involvement non BL
A
20%
13
Q
Tx of BL with CNS involvement
A
CODOX-M/IVAC
14
Q
Rearrangemnts in BL
A
t(8:14)
MYC+
BCL2-, BCL6-
