BL facts

Question 1

Subtypes of BL

Answer 1

Endemic- jaw (EBV)
Sporadic- abdominal
Immunodeficiency associated- HIV

Question 2

Sporadic BL

Answer 2

Mainly pediatric
Not related to EBV
Extra nodal involvement
CNS (leptomeningeal) involvement is common- 20%

Question 3

M:F of BL

Answer 3

2:1

Question 4

Immunodeficiency associated BL

Answer 4

Nodal
Not related to CD4 counts!

Question 5

Immunophenotype BL

Answer 5

CD20, CD10, BCL6, CD79a, HLADR -positive
CD5, BCL2, TdT, CD23- negative

Question 6

Pathology of BL

Answer 6

Intermediate size uniform cells
Basophilic cytoplasm
Prominent vacuoles
Round nuclei

Question 7

OS of BL

Answer 7

5 year 80%

Question 8

Tx options for BL

Answer 8

DA-EPOCH-R
R-CODOX-M IVAC
GMALL

Question 9

BL-IPI

Answer 9

Age > 40
ECOG > 1
CNS involvement
LDH

Question 10

Tx of limited BL diseaes

Answer 10

Defined as stage I/Ii
Without LDH or bulky disease
2+1 DA-EPOCH-R

Question 11

Tx of advanced stage BL

Answer 11

6 DA-EPOCH-R
with IT MTX

Question 12

CNS involvement in BL

Answer 12

20%

Question 13

Tx of BL with CNS involvement

Answer 13

CODOX-M/IVAC

Question 14

Rearrangemnts in BL

Answer 14

t(8:14)
MYC+
BCL2-, BCL6-