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HEM TEST 2024 > PV facts > Flashcards

PV facts Flashcards

1
Q

Median age PV

A

61

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2
Q

Incidence PV

A

2/100K

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3
Q

JAK2 VAF risk factor in PV

A

> 50% VAF
related to:
Thrombosis
Splenomegaly
Progression to PMF
Leukocytosis
Higher Hb

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4
Q

MIPSS-PV

A

Age
Abnormal karyotype
SRSF2
WBC

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5
Q

2nd line Tx for PV

A

Ruxo
PEG-IFN

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6
Q

3rd line Tx for PV

A

Busulfan

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7
Q

PEG-IFN vs HU in PV 1st line

A

PROUD/Continuation-PV
Blood 2022
PEG was:
- More effective in controlling Hb and VAF reduction
- Equally effective in preventing thrombosis
- Less effective in reducing fibrosis

control arm in PROUD was already HU resistant and Tx with HU

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8
Q

Rusfertide in PV

A

Hepcidin mimetic
May lower Hb without phlebotomy
less iron def Sx

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9
Q

LDH in PV vs ET

A

LDH may be elevated in PV but not commonly elevated in ET, alarm bells for PMF

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10
Q
A
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HEM TEST 2024 (32 decks)

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