Indolent TCL facts Flashcards

1
Q

MF Tx of limited disease

A

Topical steroids
Topical mustard nitrogen
Radiotherarpy

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2
Q

MF Tx of widespread skin disease

A

Phototherapy ultraviolet A/B + psoralen
Bv
SS pts were excluded from ALCANZA trial of Bv in MF

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3
Q

MF immunophenotype

A

Cd3+, CD4+, CD8-, CD30 +/-,
aberrant loss of 1 of:
CD2, C5, CD7

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4
Q

TX of advanced MF/SS with CD30+

A

BV if CD30+
Mogamulizumab (anti- CCR4) if CD30-

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5
Q

Agents active in MF/SS

A

Romidepsin
Lenalidomide
Mogamulizumab (CCR4)
Alemtuzumab (CD52)
Bv

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6
Q

Consolidation Tx for SS

A

Auto or Allo trasplant

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7
Q

Cutaneous ALCL Tx

A

if localized- RT

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8
Q

Breast implant–associated ALCL

A

CD30+
ALK-
Tx is surgical removal of implants
if more nodal disease- Tx like RT or Bv-CHP

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9
Q

T-LGL immunophenotype

A

CD3 and CD8 positive
CD57/CD16 positive
CD56 negative

3+57=60
8+16=24

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10
Q

NK-LGL immunophenotype

A

CD2+, CD8+,CD16+. CD56+
sCD3− , CD4-, CD57-

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11
Q

LGLL Tx

A

MTX/CY/CsA
+/- prednisone
2nd line- alemtuzumab
Consider splenectomy

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12
Q

LGLL driver mutation

A

STAT3

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