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HEM TEST 2024 > ITP facts > Flashcards

ITP facts Flashcards

1
Q

M:F in ITP

A

Females of child baring age
M:F 1:1 for age 60

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2
Q

Serious bleeding in ITP

A

5-6%

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3
Q

Anti-GP ab in ITP

A

specific but not sensitive
good for confirmation but cannot distinguish primary and secondary

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4
Q

Phases of ITP

A

< 3 months - newly diagnosed
3-12 months- persistent
>12 months- chronic

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5
Q

Occult cerebral microbleeds in ITP %

A

50%
in pts with PLT<30

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6
Q

Rituximab addition in 1st line in ITP

A

better sustained response rates
but no benefit in ORR in 1 year
not recommended

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7
Q

2nd line options for ITP

A

Rituximab
TPO-RA
Fosfamatinib

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8
Q

3rd line option for ITP

A

Splenectomy

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9
Q

Persistent/Chronic ITP %

A

60-70%

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10
Q

TPO-RA ORR in ITP

A

85%

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11
Q

Rituximab ORR in ITP

A

60-70%
achieved after 4-8 weeks
most will relapse after 6 months

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12
Q

Fostamatinib ORR in ITP

A

40%
with durable response

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13
Q

Splenectomy in ITP ORR

A

60-70%
long term durable response rates
usually 3rd/4th line
at least 12-24 months after diagnosis

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14
Q

Novel therapies in ITP

A

Rozanolixizumab
Efgartigimod
Sutimlimab
BTKi

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15
Q

Platelet counts for delivery

A

50K vaginal
70k CS
80K for epidural anesthesia

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16
Q

Tx options for pregnant ITP pts

A

Prednisone
IVIG
rhTPo (available in china)
Azathioprine
Cyclosporine A

17
Q

Response/Remission on steroids in ITP

A

75% Response
but only 20-30% long term remisssion

18
Q

Steroid length of Tx in ITP

A

taper in order to stop by 6-8 weeks

19
Q

Rituximab subpopulation effectiveness in ITP

A

younger females with short disease duration

20
Q

Avatrombopag advantage over eltrombopag in ITP

A

no food interactions
no need for liver enzyme follow up

21
Q

TPO-RA switch effectiveness in ITP

A

50-80%

22
Q

Remission of ITP after TPO-RA discontinuation

A

10-30%

23
Q

Durable response rates of 2nd line Tx in ITP

A

TPO-RA- 65%
Rituximab 40%
Fostamatinib 20%

24
Q

Upshaw-Schulman syndrome

A

Hereditary TTP

HEM TEST 2024 (32 decks)

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