CMML facts

Question 1

Somatic mutations in CMML- prognosis

Answer 1

TET2- good
ASXL1 DNMT3A, RUNX1, RAS, SRSF2- poor

Question 2

Proliferative vs dysplastic CMML

Answer 2

13K WBC

Question 3

CMML1

Answer 3

<5% PB blasts
<10% BM blasts

Question 4

CMML2

Answer 4

5-19% PB blasts
10-19 BM blasts

Question 5

CMML monocyte phnotype

Answer 5

CD14+/CD16- (classical) >94%
in reactive monocytosis CD16+ monocytes are common

Question 6

importance of clonal plasmocytic dendritic cells in CMML BMB

Answer 6

30% of biopsies
risk for developing AML

Question 7

Clonal cytogentic changes in CMML %

Answer 7

20-30%

Question 8

Common cytogenetic alterations in CMML

Answer 8

trisomy 8
-Y
del 7
trisomy 21
complex

Question 9

poor risk cytogenetics in CMML

Answer 9

trisomy 8, del 7, complex

Question 10

Autoimmune diseases in CMML %

Answer 10

20-30%

Question 11

favorable risk cytogenetics in CMML

Answer 11

-Y, normal

Question 12

Which test is important in CMML pts with AI

Answer 12

UBA1
to check for vexas

Question 13

mutations in correlation to autoimmune diseases in CMML

Answer 13

TET2
SRSF2
IDH

Question 14

Presence of renal disease in CMML

Answer 14

35% AKI
7% CKD
can be due to lysozyme renal toxicity- nictitating HMA Tx

Question 15

CMML monocyte count diagnostic criteria

Answer 15

500
and 10%

Question 16

Supporting criteria for CMML diagnosis

Answer 16

Dysplasia
Cytogenetic/Molecular abnormalities
High (>94%) monocyte FACS- CD14+CD16-

Question 17

Cells counting as blasts in CMML

Answer 17

Blasts and promonocytes