MZL facts

Question 1

gastric MALT % with HP

Answer 1

66%

Question 2

BM involvement in MALT

Answer 2

< 10%
no need for BMB

Question 3

POD24 in MALT

Answer 3

inferior OS
increased risk of transformation

Question 4

MLT-IPI

Answer 4

age>70
LDH
Stage III/IV

Question 5

HP eradication in gastric MALT

Answer 5

70% CR

Question 6

Tests after eradication of HP

Answer 6

Confirm eradication 6 weeks after Tx, and 2 weeks after PPI discontinuation
Repeat endoscopy 3 mon after eradication

Question 7

Timing of endoscopic FU after eradication of HP in gastric MALT

Answer 7

Not sooner than 3 months after eradication
Then every 3 months for 12 months
Define disease progression only after 12 months,

Question 8

pts predicted to not respond to eradication in gastric MALT

Answer 8

t(11:18)
HP negative
Tx with RT

Question 9

Tx of ocular MALT

Answer 9

Doxycycline 6 months- pulsatile
50-75% ORR

Question 10

RT dosage for ocular MALT

Answer 10

4 Gy
in order to reduce catarct

Question 11

Ocular MALT pathogen

Answer 11

C. psittaci

Question 12

Bronchial MALT Tx

Answer 12

Surgical resection
RT for remaining lympoma
RX4 for no resectable tumors

Question 13

Dural EMZL

Answer 13

More common than DLBCL of dura
usually diagnosed after resection
Tx choice is RT if not already resected

Question 14

Colonic EMZL

Answer 14

rare
usually polypectomy is enough

Question 15

Thyroid EMZL

Answer 15

Rare
usually due to autoimmune thyroiditis
resection is possible

Question 16

Salivary gland EMZL

Answer 16

rare
due to sjogren
surgery is possible

Question 17

Primary cutaneous MZL

Answer 17

Burellia burgerdofi
Good prognosis
RT

Question 18

1st line Tx of advanced NMZL

Answer 18

BR X 4

Question 19

R main in Adavnced NMZL

Answer 19

Better PFS with no OS benefit
More toxicity
Not approved

Question 20

Nodal MZL %

Answer 20

10% of MZL

Question 21

Association of nodal MZL

Answer 21

HCV
Eradication leads to lymphoma
Regression in the majority of patients

Question 22

IgM paraprotein in nodal MZL %

Answer 22

10%
confuses with WM

Question 23

Mutation specific for NMZL

Answer 23

PTPRD

Question 24

SMZL %

Answer 24

20% of MZL

Question 25

Transformation of SMZL to DLBCL %

Answer 25

5-10%

Question 26

Tx of SMZL

Answer 26

R X4 BR

Question 27

2nd line Tx of NMZL

Answer 27

Zanu/Acala Lenalidomide Bi-specific Ab

Question 28

3rd line for NMZL

Answer 28

Bi-specific Ab CART (ZUMA 5)

Question 29

2nd line for gastric MALT after eradication

Answer 29

RT

Question 30

Prognostic score for SMZL

Answer 30

HPLL Hemoglobin, PLT, LDH, Lymphadenopathy

Question 31

Prognostic factor for NMZL

Answer 31

Age

Question 32

Tx of frail pts with advanced symptomatic ENMZL

Answer 32

R If bulky disease- R+Chlorambucil

Question 33

Duration of Tx for eradication of HP in MALT

Answer 33

14 days

Question 34

Tx of HP negative MALT

Answer 34

Eradication still sometimes effective But guidelines are RT

Question 35

R maintenance in SMZL

Answer 35

PFS Not approved