Sulfas Flashcards
What are the intermediate acting sulfas?
Sulfaimethoxine, Sulfamethoxazole, Sulfamethazine, Sulfadiazine
Why is sulfa (Albon) a common residue even after a withdrawal period?
Variation in elimination between ill and healthy animals
What are the long acting sulfas?
Sulfadimethoxine, sulfamethazine
What is the enteric sulfa? Which species should you use caution in? Why?
Sulfasalazine
Be careful in cats (especially with IBS/leaky gut) because of salicylic acid
What are the diaminopyrimidines?
Trimethoprim, Ormethoprim
What are come common combinations?
Trimethoprim/sulfa, ormethoprim/sulfa, trimethoprim/sulfamethoxazole
Can you use sulfas in lactating dairy cattle?
Only approved use of sulfadimethoxine (most important), sulfabromomethazine, sulfaethoxypyridazine
Are sulfas soluble in solution?
Each sulfa has independent solubility in solution
Are sulfas acids or bases?
Weak acids
Are sulfas water soluble in acid form?
No
If you treat a sulfa with a strong base, what will it form?
Soluble, sodium salt
Are sulfa sodium salts acidic or basic? What is the pH? What’s the exception?
Basic 9 - 11
Sulfacetamide is neutral
Which sulfa is used an opthalmic solution? Why?
Sulfacetamide because it’s neutral
Is trimethoprim an acid or base?
Weak base (pKA 7.6)
Is trimethoprim water or lipid soluble?
Lipid
Why are sodium salts delivered IV only and never IM?
Very caustic due to alkalinity
What is the MOA of sulfas?
Sulfas compete with PABA for incorporation in to folic acid synthesis. Folic acid is necessary for purine synthesis. Decreases RNA and inhibits protein synthesis
What can cause sulfas decreased activity? Why?
cellular debris from folic acid is readily available from the environment
Why is it difficult to extrapolate lab susceptbility to clinical efficacy?
Cellular debris effect & bacterial-inoculum effect
Are Sulfas bacteristatic or bactericidal?
Static but can be -cidal when combined with trimethoprim
What happens when you combine a sulfa with a diaminopyrimidine?
Synergistic combo acting in bactericidal manner against susceptible microbes