Carbapenems Flashcards
Are there veterinary labels for Carbapenems?
No, all human
What are the carbapenems?
Imipenem, Meropenem
What is the MOA of carbapenems?
Covalent binding to penicillin binding proteins
Should you commonly use Imipenem? Why or why not?
No Widest spectrum (definitely widest of B-lactams)
What bacteria are Carbapenems most active against?
Pseudomonas & enterobacteriaceae
Which bacteria has shown resistance to carbapenems? Why?
Pseudomonas. Resistance can develop during treatment due to B-lactamase
What is CRE?
Carbapenemase-producing enterobacteriaceae
What are the routes of administration for Carbapenems?
IM & SC
Why is lidocaine administered with Carbapenems?
Control pain
Which carbapenem and which routeof administration is most favorable in dogs?
SQ meropenem
What is the most common side effect of carbapenems?
GI disturbance
Which carbapenem has shown CNS toxicity?
Imipenem
Caution should be used in patients that have experienced what kind of trauma or other CNS disorder?
Head trauma, seizures
What is the advantage of SQ meropenem vs Imipenem in dogs?
Meropenem is 100% absorbed from SQ injection without the pain associated with Imipenem.
Is meropenem or Imipenem more soluble? Why does this matter?
Meropenem is more soluble than Imipenem so injection volume is lower
