Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology II > Lincosamides > Flashcards

Lincosamides Flashcards

1
Q

What are the lincosamides?

A

Lincomycin, Clindamycin, Pirlimycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Are lincosamides acidic or basic?

A

Basic (pKa = 7.6)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Are lincosamides water or lipid soluble?

A

Lipid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which antimicrobial are lincosamides similar to in regards to pharmacokinetics and spectrum?

A

Macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the MOA of lincosamides?

A

Inhibit protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Are lincosamides bacteristatic or bactericidal?

A

Bacteristatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Why have clindamycin been used and considered effective against dermal Staph infections?

A

Toxin production-inhibiting effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the spectrum of lincosamides?

A

Anaerobes: +++++
Gram+ Aerobes: +++++
Gram - Aerobes: ++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Are lincosamides effective against Mycoplasma?

A

Yes, similar to erythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why are most gram - bacteria resistant to lincosamides?

A

Impermeable cell membrane & incompatible binding sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Is there cross resistance between lincosamides? What about any other abx?

A

Yes, and also with macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Give an example of inducible resistance in lincosamides

A

Bacteria with existing resistance to erythromycin rapidly develop lincosamide resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Why would food decrease the rate of absorption and bioavailability of lincomycin?

A

55 - 75% protein bound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Does food affect the bioavailability of Clindamycin (specifically)?

A

No, slows rate of absorption but does not affect bioavailability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the efficacy of lincosamides based on?

A

Time above MIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Are cats on the label for capsules of lincosamides?

A

No, liquid only

17
Q

What is a concern with Clindamycin capsules in cats? What other abx is this seen with?

A

Esophageal damage from partially swallowed pill and no water. Also seen with doxycycline

18
Q

Are all Lincosamide breakpoints CLSI approved?

A

Yes

19
Q

What species are on the Lincosamides table? Which breakpoint do you use with pigs?

A

CLindamycin in dogs for soft tissue
Pirlimycin for cattle mastitis

Use dog/soft tissue in pigs

20
Q

Can lincosamides be given to horses, rabbits, hamsters or guinea pigs? Why?

A

No, may be fatal in nonruminant herbivores but depleting anaerobe population

21
Q

What is a possible side effect of dosing a lactating animal with lincosamides?

A

Diarrhea in offspring

22
Q

Can you treat toxo in cats with Clindamycin? Which side effects should be watched for?

A

Yes, caution in cats with pulmonic toxoplasmosis (high mortality)

23
Q

How is lincomysin eliminated?

A

Hepatic (primarily hepatic with secretion via urine)

Pharmacology II (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions