Aminocyclitols Flashcards
What is the important aminoclyclitols?
Spectinomycin
Are amincyclitols hydrophilic?
Yes, poorly lipid soluble
What is the MOA of aminocyclitols?
Protein synthesis inhibitor
Are aminocyclitols bactericidal or bacteriostatic?
Bacteriostatic (can be -cidal @ 4x MIC)
What is the spectrum for aminocyclitols?
++ Gram(+)
++++ Gram(-)
Mycoplasma
Is spectinomycin potent? What is a common MIC for “susceptible” bacteria?
No
20 - 30 ug/mL
Dooes Spectinomycin have a high %PO?
No
Is there systemic activity after oral administration? Is there significant GI activity?
No systemic
Yes GI
What routes can you give spectinomycin for significant systemic effects?
IM, IV, SQ
What are the elimination times of spectinomycin?
Very short, 1 - 3 hours
What is the Vd of spectinomycin?
Very low
Are aminocyclitols as nephrotoxic as aminoglycosides?
No
Are diuretics contraindicated with spectinomycin? Why?
No because not as nephrotoxic
What is the concern with aminocyclitols and general anesthesia or neuromuscular blockades?
Aminocyclitols can potentiate neuromuscular blockade
