Steroids Flashcards
0
Q
Steroids General Naming (4)
- sone (most)
- ide (3)
- olone (2)
- one (1)
- OTHER (2)
A
- sone (most)
- Bodosimide, Budenoside + Cyclosenide
- Methylprednisolone + Triamcinolone
- Cypropterone
- OTHER: Danazol + Megesterol
1
Q
Steroids Mechanism of Action (6)
- “II KISS” *
A
- Inhibits Phospholipase A2 (=>↓production of leukotrienes + prostaglandins)
- Inhibits expression of COX-2 (COX-2 makes prostaglandins)
- Kills Eosinophils + T cells
- Inhibits Macrophage migration
- Stabilizes Mast cells
- Stabilizes endothelium
**↑expression of anti-infl proteins (in nucleus) +↓expression of pro-infl proteins (in cytosol) **
2
Q
Corticosteroids
Contraindications?
A
CI:
- Chronic viral infections
3
Q
Beclomethasone + Betamethasone
Use?
* THINK: B for Breathing *
A
USE:
-↑surfactant production
4
Q
Dexamethasone
Feature, Use?
A
Best CNS penetration of all steroids.
USE:
- Dexamethasone Suppression Test
5
Q
Fludrocortisone
Feature?
* THINK: FLUIDcortisone *
A
Can take place of Aldosterone.
6
Q
Cypropterone
Mech, Use?
A
MECH: Blocks DHT receptors
USE:
- Male-Pattern Baldness
7
Q
Danazol
Use?
A
USE:
- Endometriosis
8
Q
Megesterol
Use?
* THINK: Meg begs for food *
A
USE:
-↑appetite in Cancer patients.
