GI

Question 1

Diarrhea

Answer 1

Diphenoxylate (Opioid Analgesic) & Loperamide

Question 2

Zollinger-Ellison Sx

Answer 2

PPIs

Question 3

Antiemetic (ie post-op, chemo patients)

Answer 3

Ondansetron

Question 4

H Pylori Gastritis

Triple Therapy, Therapeutic Goals (2)?

Answer 4

RX = Triple Therapy: PPI + Amoxicillin + Clarithromycin
(Metronidazole if allergic to penicillin)
* Eradication when Urea Breath Test + Stool Antigen negative *

• > Elimination of gastritis / ulcer
• > Reversal of intestinal metaplasia

Question 5

Gastroparesis

Answer 5

Metoclopramide

Question 6

Prevention of NSAID-induced Peptic Ulcers

Answer 6

Misoprostol

Question 7

IBDs (Crohn’s + UC) (3)

Answer 7

• 6-MP
• Infliximab / Adalimumab / Natalizumab
• Sulfasalazine

Question 8

Wilson’s Dz (2)

Answer 8

• Penicillamine

- Trientine

Question 8

GI Stromal Tumors

Answer 8

Imatinib

Question 9

Colon Cancer

Answer 9

Irinotecan

Question 10

Colon + Pancreatic Cancer

Answer 10

5-FU

Question 11

Colorectal Cancer (2 Therapeutic Ab)

Answer 11

• Bevacizumab

- Cetuximab (Stage 4)

Question 12

Misoprostol (3)

Answer 12

• Maintenance of PDA
• Prevention of NSAID-induced peptic ulcers
• Labor induction (due to vasoconstriction)

Question 13

Lactulose

Mech (2 steps), Use?

Answer 13

Gut flora degrade it into metabolites (acetic acid + lactic acid) ->
Metabolites promote N excretion as NH4+.

USES:
- Hepatic Encephalopathy