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Drug Uses > IMMUNO > Flashcards

IMMUNO Flashcards

1
Q

Immuno Drugs ~GENERAL~

Uses (4), Mech?

A

USES:

  • Prevention of transplant rejection
  • Autoimmune disorders (ie HLA-B27: “CRAP”)
  • Infl conditions
  • Cancer therapy

MECH = Blocks production of IL-2 and its receptor.

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2
Q

Autoimmune Dz INCL Glomerulonephritis + Hemolytic Anemia

A

Azathioprine

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3
Q

HLA-B27 “CRAP”: Crohn’s, RA, Ankylosing Spondylitis, Psoriatic Arthritis

A

INFLiximab

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4
Q

HLA-B27 “Less CRAP = CRP”: Crohn’s, RA, Psoriatic Arthritis (2)

A
  • Adalimumab

- Etanercept

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5
Q

Cardiac Ischemia + MI

A

Abciximab / EptiFIBAtide / TiroFIBAn

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6
Q

Severe Asthma (additional line of treatment)

A

Omalizumab

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7
Q

Osteoporosis

Target?

A

Denosumab (THINK: “Density” and “os”)

TARGET = RANKL

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8
Q

Thrombocytopenia (3)

A
  • Thrombopoietin
  • Eltrombopah / Romiplostim
  • Oprelvekin (IL-11 recombinant cytokine)
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9
Q

Recovery of BM (2)

A

IL-3 recombinant cytokines:

  • Filgrastim (granulocyte colony-stim factor)
  • Sargramostim (granulocyte + macrophage colony-stim factor)
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10
Q

Paroxysmal Nocturnal Hematuria

A

Eculizumab

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11
Q

Cyclosporine

Mech (4 steps)?

A 
MECH:
Binds to cyclophilins ->
Inhibits calcineurin -> 
Blocks activation of T cells ->
Prevents production of IL-2 and its receptor.
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12
Q

Tacrolimus

Mech (1 difference from Cyclosporine Mech)?

A

MECH:

Binds to FK-binding protein = FK506

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13
Q

Sirolimus / Rapamycin

Mech (1 difference from Tacrolimus Mech)?

A

MECH:
Inhibits mTOR

THINK: SEEroLIMus: “Sees” (recognizes) IL-2 -> “Limits” T cell prolif.

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13
Q

Muromonab-CD3 / OKT3

  • THINK: MORONonab: “3 stooges are morons”. *

Target, Mech (2 steps)?

A

TARGET = CD3 on T cells

MECH = Antibody to CD3 on T cells -> Blocks T cell transduction

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14
Q

Daclizumab / Basiliximab

Target, Mech, Use?

A

TARGET = IL-2 receptor

MECH = Ab against IL-2 receptor

USE:
- Kidney transplants

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15
Q

TNF-a / Cachexin Targets (4)

A
  • Infliximab
  • Adalimumab
  • Etanercept
  • Thalidamide
16
Q

Abciximab / EptiFIBAtide / TiroFIBAn

Target, Uses (2)?

A

TARGET = Glycoprotein IIb / IIIa (glycoprotein found on platelets => role in clotting cascade)

USES:

  • Prevention of cardiac ischemia
  • MI
17
Q

Trastuzumab / Herceptin

Target, Uses (2)?

A

TARGET = erb-b2 / her-2 (protooncogene)

USES:

  • Her-2-overexpressing Breast Cancer
  • Gastric Cancer
18
Q

Rituximab

Target, Use?

A

TARGET = CD20 (CD20 found on most B cell neoplasms)

USES:
- B cell NHL

19
Q

Omalizumab

Target, Mech, Use?

A

TARGET = IgE

MECH = Prevents IgE binding to FCERI

USES:
- Severe Asthma

20
Q

Bevacizumab / Ranibizumab

*THINK: Beva and Rani *

Target, Mech, Uses (2)?

A

TARGET = VEGF

MECH = Inhibition of Angiogenesis

USES:

  • Solid tumors
  • Age-related Macular Degeneration
21
Q

Eculizumab

Target, Use?

A

TARGET = C5

USES:
- Paroxysmal Nocturnal Hematuria

22
Q

Natalizumab

THINK: Many “A”s

Target, Uses (2)?

A

TARGET = A4 Integrin

USES:

  • Crohn’s
  • MS
23
Q

Palivisumab

Target, Use?

A

TARGET = RSV F Protein

USE = RSV prophylaxis

24
Q

ALYMtuzumab

Target, Use?

A

TARGET = CD52

USE = Chronic LYMphocytic Leukemia

25
Q

CeTUXimab

Target, Uses (2)?

A

TARGET = EGFR

USES:

  • Stage 4 CRC
  • Head + Neck Cancers
28
Q

VemaRAFenib

Target, Use?

A

TARGET = B-RAF Kinase

USE = Metastatic Melanoma

29
Q

Mycophenolate

Target, Mech (2 steps), Uses (2)?

A

TARGET = Inosine Monophosphate Dehydrogenase

MECH:
Prevents production of Guanine ->
Stops B + T cell prolif.

USES:
( - Transplants - )
- Lupus Glomerulonephritis

30
Q

Interferon-a

Uses (6)?

A

USES:

  • Hepatitis B + C (Chronic)
  • Kaposi Sarcoma
  • Hairy Cell Leukemia
  • Malignant Melanoma
  • Renal Cell Carcinoma
  • Condyloma Acuminatum
31
Q

Interferon-b

Use?

A

USE = MS

32
Q

Interferon-y

Use?

A

USE = Chronic Granulomatous Dz

NADPH Oxidase def

33
Q

Thalidamide / Contergan

Target, Uses (2)?

A

TARGET = TNF-a

USES:
- Immunosuppression -
* - Anti-angiogenic

34
Q

Aldesleukin: IL-2 recombinant cytokine

THINK: Al”dos”leukin

Uses (2)?

A

USES:

  • Metastatic Melanoma
  • Renal Cell Carcinoma

Drug Uses (18 decks)

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