IMMUNO Flashcards
Immuno Drugs ~GENERAL~
Uses (4), Mech?
USES:
- Prevention of transplant rejection
- Autoimmune disorders (ie HLA-B27: “CRAP”)
- Infl conditions
- Cancer therapy
MECH = Blocks production of IL-2 and its receptor.
Autoimmune Dz INCL Glomerulonephritis + Hemolytic Anemia
Azathioprine
HLA-B27 “CRAP”: Crohn’s, RA, Ankylosing Spondylitis, Psoriatic Arthritis
INFLiximab
HLA-B27 “Less CRAP = CRP”: Crohn’s, RA, Psoriatic Arthritis (2)
- Adalimumab
- Etanercept
Cardiac Ischemia + MI
Abciximab / EptiFIBAtide / TiroFIBAn
Severe Asthma (additional line of treatment)
Omalizumab
Osteoporosis
Target?
Denosumab (THINK: “Density” and “os”)
TARGET = RANKL
Thrombocytopenia (3)
- Thrombopoietin
- Eltrombopah / Romiplostim
- Oprelvekin (IL-11 recombinant cytokine)
Recovery of BM (2)
IL-3 recombinant cytokines:
- Filgrastim (granulocyte colony-stim factor)
- Sargramostim (granulocyte + macrophage colony-stim factor)
Paroxysmal Nocturnal Hematuria
Eculizumab
Cyclosporine
Mech (4 steps)?
MECH: Binds to cyclophilins -> Inhibits calcineurin -> Blocks activation of T cells -> Prevents production of IL-2 and its receptor.
Tacrolimus
Mech (1 difference from Cyclosporine Mech)?
MECH:
Binds to FK-binding protein = FK506
Sirolimus / Rapamycin
Mech (1 difference from Tacrolimus Mech)?
MECH:
Inhibits mTOR
THINK: SEEroLIMus: “Sees” (recognizes) IL-2 -> “Limits” T cell prolif.
Muromonab-CD3 / OKT3
- THINK: MORONonab: “3 stooges are morons”. *
Target, Mech (2 steps)?
TARGET = CD3 on T cells
MECH = Antibody to CD3 on T cells -> Blocks T cell transduction
Daclizumab / Basiliximab
Target, Mech, Use?
TARGET = IL-2 receptor
MECH = Ab against IL-2 receptor
USE:
- Kidney transplants
TNF-a / Cachexin Targets (4)
- Infliximab
- Adalimumab
- Etanercept
- Thalidamide
Abciximab / EptiFIBAtide / TiroFIBAn
Target, Uses (2)?
TARGET = Glycoprotein IIb / IIIa (glycoprotein found on platelets => role in clotting cascade)
USES:
- Prevention of cardiac ischemia
- MI
Trastuzumab / Herceptin
Target, Uses (2)?
TARGET = erb-b2 / her-2 (protooncogene)
USES:
- Her-2-overexpressing Breast Cancer
- Gastric Cancer
Rituximab
Target, Use?
TARGET = CD20 (CD20 found on most B cell neoplasms)
USES:
- B cell NHL
Omalizumab
Target, Mech, Use?
TARGET = IgE
MECH = Prevents IgE binding to FCERI
USES:
- Severe Asthma
Bevacizumab / Ranibizumab
*THINK: Beva and Rani *
Target, Mech, Uses (2)?
TARGET = VEGF
MECH = Inhibition of Angiogenesis
USES:
- Solid tumors
- Age-related Macular Degeneration
Eculizumab
Target, Use?
TARGET = C5
USES:
- Paroxysmal Nocturnal Hematuria
Natalizumab
THINK: Many “A”s
Target, Uses (2)?
TARGET = A4 Integrin
USES:
- Crohn’s
- MS
Palivisumab
Target, Use?
TARGET = RSV F Protein
USE = RSV prophylaxis
ALYMtuzumab
Target, Use?
TARGET = CD52
USE = Chronic LYMphocytic Leukemia
CeTUXimab
Target, Uses (2)?
TARGET = EGFR
USES:
- Stage 4 CRC
- Head + Neck Cancers
VemaRAFenib
Target, Use?
TARGET = B-RAF Kinase
USE = Metastatic Melanoma
Mycophenolate
Target, Mech (2 steps), Uses (2)?
TARGET = Inosine Monophosphate Dehydrogenase
MECH:
Prevents production of Guanine ->
Stops B + T cell prolif.
USES:
( - Transplants - )
- Lupus Glomerulonephritis
Interferon-a
Uses (6)?
USES:
- Hepatitis B + C (Chronic)
- Kaposi Sarcoma
- Hairy Cell Leukemia
- Malignant Melanoma
- Renal Cell Carcinoma
- Condyloma Acuminatum
Interferon-b
Use?
USE = MS
Interferon-y
Use?
USE = Chronic Granulomatous Dz
NADPH Oxidase def
Thalidamide / Contergan
Target, Uses (2)?
TARGET = TNF-a
USES:
- Immunosuppression -
* - Anti-angiogenic
Aldesleukin: IL-2 recombinant cytokine
THINK: Al”dos”leukin
Uses (2)?
USES:
- Metastatic Melanoma
- Renal Cell Carcinoma
