RENAL

Question 0

Glaucoma

Answer 0

Acetazolamide

Question 1

Urinary Alkalinization (2)

Answer 1

• Acetazolamide

- Potassium Citrate

Question 2

Hirsutism

Answer 2

Spironolactone

Question 3

Nephrogenic Diabetes Insipidus

PATH: Nephron not responding to ADH -> urine too dilute -> peeing too much

Answer 3

Hydrochlorothiazide

PHARM: Concentration of urine -> pee less

Question 4

Osteoporosis

Answer 4

Hydrochlorothiazide

Question 5

Recurrent Calcium Kidney Stones

Answer 5

Thiazides + Citrate

Question 6

Bladder Cancer

Answer 6

-platin

Question 7

Wilms Tumor

Answer 7

Dactinomycin

Question 8

Mannitol

Uses (3)?

Answer 8

USES:

• ↓intracranial or intraocular pressure
• Shock
• Drug overdose

Question 9

Acetazolamide

Uses (3)?

Answer 9

USES:

• Metabolic alkalosis (b/c causes acidosis)
• Altitude Sickness
• Glaucoma (↓fluid formation in eyeball)

Question 10

Furosemide

Uses (3)?

Answer 10

USES:

• Edematous states
• Htn
• Hypercalcemia

Question 11

Ethacrynic Acid

Answer 11

Diuresis in patients with sulfa allergy

Question 13

Hydrochlorothiazide

Uses (5: 3 OBV + 2)?

Answer 13

USES:

• Hypercalciuria
• Htn
• CHF
• Nephrogenic Diabetes Insipidus
• Osteoporosis

Question 14

Spironolactone

Mech?

Answer 14

MECH = Competitive ALDOSTERONE-receptor ANTAGONIST

↓Na reabs = ↑Na + H2O excretion

Question 15

Amiloride + Triamterene

Mech?

Answer 15

MECH = DIRECT inhibition of Na channels assoc with Aldosterone receptor.

Question 16

ACE Inhibitors (-pril)

Mech (2)?

Answer 16

MECH:

• Inhibit ACE -> ↓ATII -> ↓GFR (by preventing constriction of E.A) -> ↑Renin release
• Keeps Bradykinin active / prevents its inactivation