BCEM Flashcards
0
Q
Na/K ATPase Inhibitors (2)
Mech (4 steps)?
A
- Cardiac Glycosides: Digoxin + Digitoxin (direct inhib)
- Ouabain (inhib by binding to K site)
MECH:
Inhib of Na/K ATPase -> Indirect Inhib of Na/Ca EXCHANGE ->
↑intracel Ca -> ↑cardiac contractility
1
Q
Drugs that Act on Microtubules (5)?
THINK: “Microtubules Get Constructed Very Poorly”
A
- Colchicine (anti-gout)
- Griseofulvin (anti-fungal)
- Mebendazole / Thiabendazole (anti-helminthic)
- Paclitaxel (anti- Breast Cancer)
- Vinblastine / Vincristine (anti-Cancer)
2
Q
N-Acetylcysteine
Mech?
A
Cystic Fibrosis
MECH:
- Loosens mucus plugs (cleaves disulfide bonds within mucus glycoproteins)
