Spring Quiz 6

Question 1

Quetiapine (Brand, Class, MOA)

Answer 1

Seroquel, Seroquel XR. Atypical 2nd gen Antipsychotic. Combo of DA type 2 (D2) and 5HT type 2 (5-HT2) antagonism.

Question 2

Quetiapine (Indication, BBW, Preg)

Answer 2

Schizophrenia. Inc mortality in elderly pts w dementia-related psychosis, suicidal thoughts and behaviors. No.

Question 3

Aripiprazole (Brand, Class, MOA)

Answer 3

Abilify, Abilify Maintena (inj). Atypical 2nd gen Antipsychotic. Partial agonist at the DA type 2 and 5-HT type 1Areceptors, and as an antagonist at the 5-HT type 2Areceptor.

Question 4

Aripiprazole (Indication, BBW, Preg)

Answer 4

Schizophrenia. Inc mortality in elderly pts w dementia-related psychosis, suicidal thoughts and behaviors. No.

Question 5

Clozapine (Brand, Class, MOA)

Answer 5

Clozaril. Atypical 2nd gen Antipsychotic. DA type 2 (D2) and 5-HT type 2A (5-HT2A) receptors.

Question 6

Clozapine (Indication, BBW, Preg)

Answer 6

Tx resistant schizophrenia, suicidal behavior w/ schizophrenia, or schizoaffective disorder. Inc mortality in elderly pts w dementia-related psychosis, severe neutropenia, orthostatic HTN, bradycardia, syncope, seizures. No.

Question 7

Chlorpromazine (Brand, Class, MOA)

Answer 7

None. Typical 1st gen Antipsychotic, Antimanic Agent. Blocks postsynaptic mesolimbic DA receptors in the brain, and exhibits a strong alpha blocking effect and depresses the release of hypothalamic and hypophyseal hormones

Question 8

Chlorpromazine (Indication, BBW, Preg)

Answer 8

Schizophrenia/psychotic disorders, bipolar disorder, and behavioral problems (hyper excitability). Increased mortality in elderly patients with dementia-related psychosis. No.

Question 9

Haloperidol (Brand, Class, MOA)

Answer 9

Haldol, Haldol Decanoate. Typical 1st gen Antipsychotic, Antimanic Agent. Nonselectively blocks postsynaptic DA type 2 receptors in the brain.

Question 10

Haloperidol (Indication, BBW, Preg)

Answer 10

Schizophrenia/ hyperactivity/ psychotic disorders/ behavior disorders (hyper excitability). Increased mortality in elderly patients with dementia-related psychosis. No.

Question 11

Benztropine (Brand, Class, MOA)

Answer 11

Cogentin. Anticholinergic Agent, Anti-Parkinson’s Agent. Possesses both anticholinergic and antihistaminic effects.

Question 12

Benztropine (Indication, BBW, Preg)

Answer 12

Aid in the control of extrapyramidal disorders (except tardive dyskinesia) due to neuroleptic drugs, Parkinsonism. None. No.

Question 13

Perphenazine (Brand, Class, MOA)

Answer 13

None. Typical 1st gen Antipsychotic, Antiemetic. Possesses both anticholinergic and antihistaminic effects.

Question 14

Perphenazine (Indication, BBW, Preg)

Answer 14

Tx of schizophrenia; severe N/V. Inc mortality in elderly patients with dementia-related psychosis. No.

Question 15

Venlafaxine (Brand, Class, MOA)

Answer 15

Effexor XR. SNRI. Potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine functions like an SSRI in low doses (37.5 mg/day) and as a dual mechanism agent affecting serotonin and norepinephrine at doses above 225 mg/day.

Question 16

Venlafaxine (Indication, BBW, Preg)

Answer 16

Depression. Suicidal thoughts and behaviors. No.

Question 17

Citalopram (Brand, Class, MOA)

Answer 17

Celexa. SSRI. Selectively inhibits 5-HT reuptake in the presynaptic neurons and has minimal effects on NE or DA.

Question 18

Citalopram (Indication, BBW, Preg)

Answer 18

Depression. Suicidal thoughts and behaviors. No.

Question 19

Selegiline (Brand, Class, MOA)

Answer 19

Emsam (transdermal), Eldepryl, Zelapar. Type B MAOI, Anti-Parkinson’s Agent. Potent, irreversible inhibitor of monoamine oxidase (MAO).

Question 20

Selegiline (Indication, BBW, Preg)

Answer 20

PD, Major Depressive Disorder. Suicidal thoughts and behaviors (patch). No.

Question 21

Amitriptyline (Brand, Class, MOA)

Answer 21

Elavil. Antidepressant, Tricyclic (Tertiary Amine). Inc the synaptic conc of 5-HT and/or NE in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane pump.

Question 22

Amitriptyline (Indication, BBW, Preg)

Answer 22

Depression. Suicidal thoughts and behaviors. No.

Question 23

Bupropion (Brand, Class, MOA)

Answer 23

Wellbutrin, Wellbutrin SR, Wellbutrin XL. Dopamine-Reuptake Inhibitor. Weak inhibitor of the neuronal uptake of NE and DA, and does not inhibit MAO or the reuptake of 5-HT. Metabolite inhibits the reuptake of NE.

Question 24

Bupropion (Indication, BBW, Preg)

Answer 24

Depression. Suicidal thoughts and behaviors, severe neuropsychiatric events when used for smoking cessation. No.