Spring Quiz 3

Question 1

Warfarin (Brand, Class, MOA)

Answer 1

Coumadin. Vit K antagonist. Hepatic synthesis of coagulation factors II, VII, IX, and X, as well as proteins C and S, requires the presence of vitamin K.

Question 2

Warfarin (Indication, BBW, Preg)

Answer 2

Ppx or tx of thrombus or embolism. Major or fatal bleeding risk. X.

Question 3

Clopidogrel (Brand, Class, MOA)

Answer 3

Plavix. Antiplatelet agent. in vivobiotransformation to an active thiol metabolite. The active metabolite irreversibly blocks the P2Y12component of ADP receptors on the platelet surface, which prevents activation of the GPIIb/IIIa receptor complex, thereby red

Question 4

Clopidogrel (Indication, BBW, Preg)

Answer 4

S/p MI, stroke, acute coronary syndrome. Diminished effectiveness in poor metabolizers. No.

Question 5

Ticagrelor (Brand, Class, MOA)

Answer 5

Brilinta. Antiplatelet Agent. Reversibly and noncompetitively binds the ADP P2Y12receptor on the platelet surface which prevents ADP-mediated activation of the GPIIb/IIIa receptor complex reducing platelet aggregation. Due to the reversible antagonism of the P2Y12receptor.

Question 6

Ticagrelor (Indication, BBW, Preg)

Answer 6

Acute Coronary Syndrome. Major or fatal bleeding risk. No.

Question 7

Aspirin (Brand, Class, MOA)

Answer 7

Various. Antiplatelet Salicylate, NSAID. irreversibly inhibits COX-1 and 2 enzymes, via acetylation, which results in decreased formation of prostaglandin precursors; irreversibly inhibits formation of prostaglandin derivative, thromboxane A2, via acetylation of platelet.

Question 8

Aspirin (Indication, BBW, Preg)

Answer 8

Analgesic, MI, Stroke, Angina. No. No.

Question 9

Enoxaparin (Brand, Class, MOA)

Answer 9

Lovenox. LMWH. Anticoagulant by enhancing the inhibition rate of clotting proteases by antithrombin III impairing normal hemostasis and inhibition of factor Xa. Enoxaparin has a higher ratio of antifactor Xa to antifactor IIa activity than unfractionated heparin.

Question 10

Enoxaparin (Indication, BBW, Preg)

Answer 10

Acute Coronary Syndrome, DVT ppx/tx. Spinal/epidural hematoma. No.

Question 11

Dabigatran (Brand, Class, MOA)

Answer 11

Pradaxa. Anticoagulant, thrombin inhibitor. Prodrug lacking anticoagulant activity that is convertedin vivoto the active dabigatran, a specific, reversible, direct thrombin inhibitor that inhibits both free and fibrin-bound thrombin.

Question 12

Dabigatran (Indication, BBW, Preg)

Answer 12

DVT/PE tx and ppx, nonvalvular atrial fibrillation.. Spinal/epidural hematoma, Thrombotic Events. No.

Question 13

Fondaparinux (Brand, Class, MOA)

Answer 13

Arixtra. Anticoagulant, Factor Xa inhibitor. Synthetic pentasaccharide that causes an antithrombin III-mediated selective inhibition of factor Xa. Neutralization of factor Xa interrupts the blood coagulation cascade and inhibits thrombin formation and thrombus development.

Question 14

Fondaparinux (Indication, BBW, Preg)

Answer 14

Acute DVT/PE and DVT ppx. Spinal/epidural hematoma. No.

Question 15

Rivaroxaban (Brand, Class, MOA)

Answer 15

Xarelto. Anticoagulant, Factor Xa inhibitor. inhibits platelet activation and fibrin clot formation via direct, selective and reversible inhibition of factor Xa (FXa) in both the intrinsic and extrinsic coagulation pathways.

Question 16

Rivaroxaban (Indication, BBW, Preg)

Answer 16

Acute DVT/PE and DVT ppx, Nonvalvular atrial fibrillation. Spinal/epidural hematoma, Premature d/c inc risk of thrombotic events. No.

Question 17

Alteplase (Brand, Class, MOA)

Answer 17

Activase. Thrombolytic Agent. initiates local fibrinolysis by binding to fibrin in a thrombus (clot) and converts entrapped plasminogen to plasmin.

Question 18

Alteplase (Indication, BBW, Preg)

Answer 18

Acute ischemic stroke, PE, ST-elevation MI. No. No.

Question 19

Ranolazine (Brand, Class, MOA)

Answer 19

Ranexa. Antianginal agent. inhibits the late phase of the inward sodium channel (late INa) in ischemic cardiac myocytes during cardiac repolarization reducing intracellular sodium concentrations and thereby reducing calcium influx via Na+-Ca2+exchange.

Question 20

Ranolazine (Indication, BBW, Preg)

Answer 20

Chronic angina. No. No.

Question 21

Amiodarone (Brand, Class, MOA)

Answer 21

Cordarone, Pacerone. Class III Antiarrhythmic Agent. Class III antiarrhythmic agent which inhibits adrenergic stimulation (alpha- and beta-blocking properties), affects sodium, potassium, and calcium channels, prolongs the action potential and refractory period in myocardial tissue; decreases AV conduction and sinus node function.

Question 22

Amiodarone (Indication, BBW, Preg)

Answer 22

Mgmt of life-threatening recurrent VF or recurrent hemodynamically-unstable VT refractory to other antiarrhythmic agents or in pts intolerant of other agents. Life-threatening arrhythmias, potentially fatal toxicities, high-risk patients. No.

Question 23

Dofetilide (Brand, Class, MOA)

Answer 23

Tikosyn. Class III Antiarrhythmic Agent. Blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current. Dofetilide has no effect on sodium channels, adrenergic alpha-receptors, or adrenergic beta-receptors. It increases the monophasic action potential duration due to delayed repolarization.

Question 24

Dofetilide (Indication, BBW, Preg)

Answer 24

Conversion of atrial fibrillation and atrial flutter to normal sinus rhythm. Arrhythmias. No.