Spring Quiz 4

Question 1

Sevelamer (Brand, Class, MOA)

Answer 1

Renagel, Revela. Phosphate binder. Binds phosphate within the intestinal lumen, limiting absorption and decreasing serum phosphate concentrations without altering Ca, Al, or bicarb conc.

Question 2

Sevelamer (Indication, BBW, Preg)

Answer 2

Hyperphosphatemia in pts with CKD on hemodialysis. No. No.

Question 3

Lanthanum Carbonate (Brand, Class, MOA)

Answer 3

Fosrenol. Phosphate binder. Disassociates in the upper GI tract to lanthanum ions (La3+) which bind to dietary phosphate resulting in insoluble lanthanum phosphate complexes and a net decrease in serum phosphate and calcium levels.

Question 4

Lanthanum Carbonate (Indication, BBW, Preg)

Answer 4

Reduction of serum phosphate in patients with ESRD. No. No.

Question 5

Paricalcitol (Brand, Class, MOA)

Answer 5

Zemplar. Vit D analog. Decreased renal conversion of vit D to its primary active metabolite (1,25-hydroxyvitamin D) in chronic renal failure leads to reduced activation of vitamin D receptor (VDR), which removes inhibitory suppression of PTH.

Question 6

Paricalcitol (Indication, BBW, Preg)

Answer 6

Tx/ppx of secondary hyperparathyroidism in chronic renal impairment. No. No.

Question 7

Doxercalciferol (Brand, Class, MOA)

Answer 7

Hectorol. Vit D analog. Metabolized to the active form of vitamin D which controls intestinal absorption of dietary Ca, the tubular reabsorption of Ca by the kidneys, and in conjunction with PTH, the mobilization of Ca from the skeleton.

Question 8

Doxercalciferol (Indication, BBW, Preg)

Answer 8

Tx/ppx of secondary hyperparathyroidism in chronic renal impairment No. No.

Question 9

Ferric citrate (Brand, Class, MOA)

Answer 9

Auryxia. Phosphate binder. Lowers serum phosphate by binding to dietary phosphate in the GI tract; product precipitates as insoluble ferric phosphate and is excreted in feces.

Question 10

Ferric citrate (Indication, BBW, Preg)

Answer 10

Hyperphosphatemia: For the control of serum phosphorus levels in patients with chronic kidney disease (CKD) receiving dialysis. No. No.

Question 11

Calcitriol (Brand, Class, MOA)

Answer 11

Rocaltrol. Vit D analog. Calcitriol, the active form of vit D, binds to and activates the VDR in kidney, parathyroid gland, intestine, and bone, stimulating intestinal calcium transport and absorption. It reduces PTH levels and improves calcium and phosphate homeostasis by stimulating bone resorption of calcium and increasing renal tubular reabsorption of calcium.

Question 12

Calcitriol (Indication, BBW, Preg)

Answer 12

Mgmt of hypocalcemia in pts on chronic renal dialysis, mgmt of secondary hyperparathyroidism in pts with CKD not yet on dialysis, mgmt of hypocalcemia in pts with hypoparathyroidism and pseudohypoparathyroidism. No. No.

Question 13

Cinacalcet (Brand, Class, MOA)

Answer 13

Sensipar. Calcimimetic. Increases the sensitivity of the calcium-sensing receptor on the parathyroid gland thereby, concomitantly lowering parathyroid hormone (PTH), serum calcium, and serum phosphorus levels, preventing progressive bone disease and adverse events associated with mineral metabolism disorders.

Question 14

Cinacalcet (Indication, BBW, Preg)

Answer 14

Tx of secondary hyperparathyroidism, tx of hypercalcemia, tx of hypercalcemia in pts with primary hyperparathyroidism. No. No.

Question 15

Calcium acetate (Brand, Class, MOA)

Answer 15

Phoslo. Ca salt, phosphate binder. Combines with dietary phosphate to form insoluble calcium phosphate which is excreted in feces.

Question 16

Calcium acetate (Indication, BBW, Preg)

Answer 16

Control of hyperphosphatemia in end-stage renal failure, but does not promote aluminum absorption. No. No.

Question 17

Vitamin B complex + folic acid (Brand, Class, MOA)

Answer 17

Folbic, Folbee. Vitamin. ??

Question 18

Vitamin B complex + folic acid (Indication, BBW, Preg)

Answer 18

Nutritional supplement in end-stage renal failure, dialysis, hyperhomocysteinemia, homocystinuria, malabsorption syndromes, dietary deficiencies. No. No.

Question 19

Midodrine (Brand, Class, MOA)

Answer 19

None. Alpha 1 agonist. Midodrine forms an active metabolite, desglymidodrine, which is an alpha1-agonist. This agent increases arteriolar and venous tone resulting in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension.

Question 20

Midodrine (Indication, BBW, Preg)

Answer 20

Tx of symptomatic orthostatic hypotension. Can cause increased supine BP. No.