Quiz 8

Question 1

Mometasone (Brand, Class, MOA)

Answer 1

Nasonex (nasal), Asmanex. Corticosteroid. May inhibit endogenous chem mediators of inflammation.

Question 2

Mometasone (Indication, Preg, Black box)

Answer 2

Asthmanex: Asthma. Nasonex: nasal polyps, allergic rhinitis, rhinosinusitus. No. None.

Question 3

Beclomethasone (Brand, Class, MOA)

Answer 3

QVAR. Corticosteroid. May inhibit endogenous chem mediators of inflammation.

Question 4

Beclomethasone (Indication, Preg, Black box)

Answer 4

Asthma, off label COPD. No. None.

Question 5

Fluticasone (Brand, Class, MOA)

Answer 5

Veramyst (nasal), Flonase (nasal), Flovent. Corticosteroid. May inhibit endogenous chem mediators of inflammation.

Question 6

Fluticasone (Indication, Preg, Black box)

Answer 6

Flovent: asthma, off label COPD. Veramyst/flonase: allergic rhinitis and non allergic rhinitis. May inhibit endogenous chem mediators of inflammation. Utilizes fluorocarbothioate at 17 position.

Question 7

Fluticasone/Salmeterol (Brand, Class, MOA)

Answer 7

Advair Diskus, Advair HFA. LABA/corticosteroid. Fluticasone: May inhibit endogenous chem mediators of inflammation. Salmeterol: relaxes bronchial smooth muscle by selective action on beta2-Rs with little effect on HR.

Question 8

Fluticasone/Salmeterol (Indication, Preg, Black Box)

Answer 8

Asthma. Diskus: COPD. No. Asthma related death bc LABA.

Question 9

Fluticasone Furoate/Vilanterol (Brand, Class, MOA)

Answer 9

Breo Ellipta. LABA/corticosteroid. Fluticasone: May inhibit endogenous chem mediators of inflammation. Vilanterol: relaxes bronchial smooth muscle by selective action on beta2-Rs with little effect on HR.

Question 10

Fluticasone Furoate/Vilanterol (Indication, Preg, Black box)

Answer 10

Asthma, COPD. No. Asthma related death, avoid in pts with severe milk allergies, increased risk of pneumonia.

Question 11

Budesonide (Brand, Class, MOA)

Answer 11

Pulmicort Respules or Flexhaler. Corticosteroid. May inhibit endogenous chem mediators of inflammation.

Question 12

Budesonide (Indication, Preg, Black box)

Answer 12

Asthma, obstructive airways due to COPD, Crohn’s Disease, ulcerative colitis. No. None.

Question 13

Budesonide/Formoterol (Brand, Class, MOA)

Answer 13

Symbicort. LABA/corticosteroid. Budesonide: May inhibit endogenous chem mediators of inflammation. Formoterol: relaxes bronchial smooth muscle by selective action on beta2-Rs with little effect on HR.

Question 14

Montelukast (Indication, Preg, Black box)

Answer 14

Asthma, allergic and perennial, exercise-induced bronchoconstriction/ bronchospasm. No. None.

Question 15

Albuterol (Brand, Class, MOA)

Answer 15

ProAir HFA or RespiClick, Proventil, Ventolin HFA. Beta 2 agonist (short acting rescue inhaler). Relaxes bronchial smooth muscle by action on beta2 Rs.

Question 16

Montelukast (Brand, Class, MOA)

Answer 16

Singulair. Leukotriene antagonist. inhibits the cysteinyl leukotriene receptor. Cysteinyl leukotrienes are associated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.

Question 17

Albuterol (Indication, Preg, Black box)

Answer 17

Tx/prevention bronchospasm in pts with reversible obstructive airway disease; prevention of exercise-induced bronchospasm. No. None.

Question 18

Levalbuterol (Brand, Class, MOA)

Answer 18

Xopenex HFA. Beta 2 agonist. Relaxes bronchial smooth muscle by action on beta2 Rs.

Question 19

Levalbuterol (Indication, Preg, Black Box)

Answer 19

Tx/prevention of bronchospasm in patients with reversible obstructive airway disease. No. None.

Question 20

Tiotropium (Brand, Class, MOA)

Answer 20

Spiriva Handihaler or Respimat. LAMA. Inhibits the action of acetylcholine at type 3 muscarinic (M3) receptors in bronchial smooth muscle causing bronchodilation.

Question 21

Tiotropium (Indication, Preg, Black Box)

Answer 21

COPD. No. None.

Question 22

Aclidinium Bromide (Brand, Class, MOA)

Answer 22

Tudorza Pressair. LAMA. Inhibits the action of acetylcholine at type 3 muscarinic (M3) receptors in bronchial smooth muscle causing bronchodilation

Question 23

Aclidinium Bromide (Indication, Preg, Black Box)

Answer 23

COPD. No. None.

Question 24

Ipratropium/Albuterol (Brand, Class, MOA)

Answer 24

Combivent Respimat, Duoneb. LAMA/Beta 2 agonist. Albuterol: relaxes bronchial smooth muscle by working on beta 2 receptors. Ipratropium: blocks action of Ach at parasympathetic sites in bronchial smooth muscle causing bronchodilation

Question 25

Dornase Alfa (Brand, Class, MOA)

Answer 25

Pulmozyme. Mucolytic agent. Dornase alfa is a DNA enz that selectively cleaves DNA, thus reducing mucous
viscosity and as a result, airflow in the lung is improved and the risk of bacterial infection may be decreased.

Question 26

Ipratropium/Albuterol (Indication, Preg, Black Box)

Answer 26

COPD in pts currently on reg bronchodilator who continue to have bronchospasms and need a 2nd. No. None.

Question 27

Dornase Alfa (Indication, Preg, Black Box)

Answer 27

CF. No. None.

Question 28

Omalizumab (Brand, Class, MOA)

Answer 28

Xolair. mAb. Inhibits IgE binding.

Question 29

Omalizumab (Indication, Preg, Black Box)

Answer 29

Mod to severe persistent asthma, uncontrolled with inhaled corticosteroid (12+ yo w/ pos skin test or in vitro reactivity to a perennial aeroallergen). No. Anaphylaxis, presenting as bronchospasm, hypotension, syncope, urticaria, and/or angioedema of the throat or tongue. IgE mediated rxn, specifically for peanuts.