Spring Quiz 2

Question 1

Aliskiren (Brand, Class, MOA)

Answer 1

Tekturna. Renin Inhibitor. Direct renin inhibitor, resulting in blockade of the conversion of angiotensinogen to angiotensin I.

Question 2

Aliskiren (Indication, BBW, Preg)

Answer 2

HTN. Fetal tox. No.

Question 3

Metoprolol Succinate (Brand, Class, MOA)

Answer 3

Toprol XL. Beta1 blocker. Selective inhibitor of beta1 Rs; competitively blocks beta1-Rs, with little or no effect on beta2-Rs at PO doses.

Question 4

Metoprolol Succinate (Indication, BBW, Preg)

Answer 4

HTN. Exacerbations of angina pectoris and MI when DC abruptly. Gradually reduce dose for 1-2 wks and carefully monitor: Ischemic heart disease. No.

Question 5

Carvedilol (Brand, Class, MOA)

Answer 5

Coreg, Coreg CR. Beta blocker with alpha blocking activity. As a racemic mixture, has nonselective beta-adrenoreceptor and alpha-adrenergic blocking activity.In CHF, associated effects include decreased pulmonary capillary wedge pressure, decreased pulmonary artery pressure, decreased HR, decreased systemic vascular resistance, increased stroke volume index, and decreased right atrial pressure (RAP)

Question 6

Carvedilol (Indication, BBW, Preg)

Answer 6

HF, HTN. No. No.

Question 7

Amlodipine (Brand, Class, MOA)

Answer 7

Norvasc. CCB. Inhibits Ca from entering select volt-sens areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation. Amlodipine directly acts on vascular smooth muscle to produce peripheral arterial vasodilation reducing peripheral vascular resistance and blood pressure.

Question 8

Amlodipine (Indication, BBW, Preg)

Answer 8

HTN. No. No.

Question 9

Diltiazem (Brand, Class, MOA)

Answer 9

Cardizem CD, Cardizem LA, Cartia XT. CCB. Nondihydropyridine CCB which inhibits Ca from entering or select volt-sens areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina

Question 10

Diltiazem (Indication, BBW, Preg)

Answer 10

HTN. No. No.

Question 11

Lisinopril (Brand, Class, MOA)

Answer 11

Zestril, Prinivil. ACE-I. Competitive inhibitor of ACE; prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor

Question 12

Lisinopril (Indication, BBW, Preg)

Answer 12

HTN, HF. Fetal tox. No.

Question 13

Digoxin (Brand, Class, MOA)

Answer 13

Digitek, Lanoxin. Antiarrhythmic agent. HF: Inhibition of the Na/K ATPase pump in myocardial cells results in a transient increase of intracellular Na, which in turn promotes Ca influx via the Na-Ca exchange pump leading to increased contractility. Supraventricular arrhythmias: Direct suppression of the AV node conduction to increase effective refractory period and decrease conduction velocity - positive inotropic effect, enhanced vagal tone, and decreased ventricular rate to fast atrial arrhythmias.

Question 14

Digoxin (Indication, BBW, Preg)

Answer 14

HF, atrial fibrillation. No. No.

Question 15

Nitroglycerin (Brand, Class, MOA)

Answer 15

Nitro-Bid, Nitro-Dur, Nitrostat. Antianginal agent. Forms free radical NO. In smooth muscle, NO activates guanylate cyclase which increases cGMP leading to deP of myosin light chains and smooth muscle relaxation.

Question 16

Nitroglycerin (Indication, BBW, Preg)

Answer 16

Tx or pox of angina pectoris. No. No.

Question 17

Hydralazine/isosorbide dinitrate (Brand, Class, MOA)

Answer 17

BiDil. AntiHTN agent. Hydralazine: Direct vasodilation of arterioles (with little effect on veins) resulting in decreased systemic resistance; Isosorbide Nitrate: Stimulation of intracellular cGMP results in vascular smooth muscle relaxation of both arterial and venous vasculature with more prominent effects on the veins. Primarily reduces cardiac O demand by decreasing preload (left ventricular end-diastolic pressure).

Question 18

Hydralazine/isosorbide dinitrate (Indication, BBW, Preg)

Answer 18

HF. No. No.

Question 19

Losartan (Brand, Class, MOA)

Answer 19

Cozaar. ARB. Blocks vasoconstricting and ADH effects of angiotensin 2.

Question 20

Losartan (Indication, BBW, Preg)

Answer 20

HTN, HF (off label), DM nephropathy. Fetal tox. Not X.