Quiz 2

Question 1

Isotretinoin (Brand, Class, MOA)

Answer 1

Accutane; Claravis; Zenatane. Antineoplastic agent, retinoic acid derivative. Reduces sebaceous gland size and reduces sebum production in acne tx.

Question 2

Isotretinoin (Indication, Preg, Black Box)

Answer 2

Severe recalcitrant nodularacne. X. Birth defects.

Question 3

Doxycycline (Brand, Class, MOA)

Answer 3

Oracea; Vibramycin. Antibiotic, tetracycline derivative. Inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane.

Question 4

Doxycycline (Indication, Preg, Black Box)

Answer 4

Acne, actinomycosis, acute intestinal amebiasis, anthrax, cholera, clostridium, gram-negative infections, listeriosis, malaria ppx, ophthalmic infections, relapsing fever, respiratory tract infections, rickettsial infections, rosacea (oracea only), STDs, skin and skin structure infections, vincent infection, yaws, zoonotic infections (skin infections and severe acne). Not X. None.

Question 5

Clindamycin (Brand, Class, MOA)

Answer 5

Cleocin. Antibiotic, lincosamide. Reversibly binds to 50S ribosomal subunits preventing peptide bond formation thus inhibiting bacterial protein synthesis.

Question 6

Clindamycin (Indication, Preg, Black Box)

Answer 6

Bacterial vaginosis (infections) and severe acne. Not X. Clostridium difficile –associated diarrhea (CDAD) has been reported, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of C. difficile.

Question 7

Sulfamethoxazole/Trimethoprim (Brand, Class, MOA)

Answer 7

Bactrim; Septra. Antibiotic, sulfonamide derivative. sulfamethoxazole (SMX) resembles PABA and competes with PABA to inhibit synthesis of dihydrofolic acid, which prevents the synthesis of tetrahydrofolate. Trimethoprim (TMP) inhibits an enzyme to make THF.

Question 8

Sulfamethoxazole/Trimethoprim (Indication, Preg, Black Box)

Answer 8

Acute exacerbtations of chronic bronchitis, acute otitis media, enteritis, PCP ppx, PCP tx, traverler’s diarrhea, UTIs. skin infections. off-label for acne. Not X. None.

Question 9

Cephalexin (Brand, Class, MOA)

Answer 9

Keflex. Antibiotic, first generation cephalosporin. Binds to penicillin-binding proteins (PBPs), which inhibits peptidoglycan synthesis in cell walls; bacteria eventually lyse.

Question 10

Cephalexin (Indication, Preg, Black Box)

Answer 10

Bone infections, genitourinary tract infections, otitis media, respiratory tract infections, skin and skin structure infections. Not X. None.

Question 11

Amoxicillin (Brand, Class, MOA)

Answer 11

Amoxil. Antibiotic; penicillin. Binds to penicillin-binding proteins (PBPs), which inhibits peptidoglycan synthesis in cell walls; bacteria eventually lyse.

Question 12

Amoxicillin (Indication, Preg, Black Box)

Answer 12

Ear/nose/throat infections, gonorrhea, GU tract infections, H. pylori infections, lower respiratory tract infections, skin and skin structure infections. Not X. None.

Question 13

Mupirocin (Brand, Class, MOA)

Answer 13

Bactroban. Topical antibiotic. Binds to bacterial isoleucyl transfer-RNA synthetase resulting in the inhibition of protein synthesis.

Question 14

Mupirocin (Indication, Preg, Black Box)

Answer 14

MRSA, secondarily infect skin lesions, impetigo due to S. aurreus and S. pyogenes (staph and strep). Not X. None.

Question 15

Fluconazole (Brand, Class, MOA)

Answer 15

Diflucan. Antifungal agent. Interferes with fungal cytochrome P450 activity decreases ergosterol inhibiting cell membrane formation.

Question 16

Fluconazole (Indication, Preg, Black Box)

Answer 16

Candida ppx, candidiasis, cryptococcal meningitis (yeast or candida infections). Not X. None.