Quiz 9

Question 1

Rabeprazole (Brand, Class, MOA)

Answer 1

Aciphex. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 2

Rabeprazole (Indication, Preg, Black Box)

Answer 2

Duodenal ulcers; GERD; H. pylori eradication. No. None. Genotype pts.

Question 3

Lansoprazole (Brand, Class, MOA)

Answer 3

Prevacid. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 4

Lansoprazole (Indication, Preg, Black Box)

Answer 4

Short-term (4 wks) tx of active duodenal ulcers; maintenance tx of healed duodenal ulcers; H. pylori eradication; tx of NSAID-assoc ulcer; to reduce the risk of NSAID-assoc ulcer; short-term (up to 8 wks) tx of sx GERD; short-term (up to 8 wks) tx for all grades of erosive esophagitis; Zollinger-Ellison syndrome. No. None.

Question 5

Dexlansoprazole (Brand, Class, MOA)

Answer 5

Dexilant. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 6

Dexlansoprazole (Indication, Preg, Black Box)

Answer 6

Erosive Esophagitis, GERD. No. None.

Question 7

Pantoprazole (Brand, Class, MOA)

Answer 7

Protonix. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 8

Pantoprazole (Indication, Preg, Black Box)

Answer 8

Short-term (up to 8 wks) tx and mx of healing of erosive esophagitis assoc with GERD; GERD sx; Zollinger-Ellison syndrome. No. None.

Question 9

Esomeprazole (Brand, Class, MOA)

Answer 9

Nexium. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 10

Esomeprazole (Indication, Preg, Black Box)

Answer 10

Duodenal ulcers; GERD; H. pylori eradication;Risk reduction of NSAID-assoc gastric ulcer. No. None. Recommends genotyping pts.

Question 11

Omeprazole (Brand, Class, Black Box)

Answer 11

Prilosec. PPI. Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump, metab by CYP 2C19.

Question 12

Omeprazole (Indication, Preg, Black Box)

Answer 12

GERD. No. None.

Question 13

Ranitidine (Brand, Class, Black Box)

Answer 13

Zantac. H2 blocker. Competitive inhibition of ha at H2-Rs of the gastric parietal cells, which inhibits gastric acid secretion, gastric volume, and hydrogen ion concentration are reduced.

Question 14

Ranitidine (Indication, Preg, Black Box)

Answer 14

Duodenal ulcer Short-term tx, Erosive esophagitis, Gastric ulcer, GERD, Zollinger-Ellison syndrome, Heartburn (OTC only). No. None.

Question 15

Famotidine (Brand, Class, MOA)

Answer 15

Pepcid. H2 blocker. Competitive inhibition of ha at H2-Rs of the gastric parietal cells, which inhibits gastric acid secretion, gastric volume, and hydrogen ion concentration are reduced.

Question 16

Famotidine (Indication, Preg, Black Box)

Answer 16

Duodenal ulcer; GERD; pathological hypersecretory conditions; OTC labeling: Relief of heartburn, acid indigestion, and sour stomach. No. None.

Question 17

Promethazine (Brand, Class, MOA)

Answer 17

Phenergan, Phenadoz (supp). H1 blocker (antiemetic). Competes with histamine for the H1-receptor; muscarinic-blocking effect may be responsible for antiemetic activity; reduces stimuli to the brainstem reticular system

Question 18

Promethazine (Indication, Preg, Black Box)

Answer 18

sx tx of various allergic conditions; antiemetic; motion sickness; sedative; adjunct to postoperative analgesia and anesthesia. No. Fatal respiratory depression, gangrene/tissue necrosis (severe tissue injury).

Question 19

Mesalamine (Brand, Class, MOA)

Answer 19

Asacol, Lialda. 5-aminosalicylic acid derive. Modulates local chemical mediators of the inflammatory response, especially leukotrienes, and is also postulated to be a free radical scavenger or an inhibitor of tumor necrosis factor (TNF).

Question 20

Mesalamine (Indication, Preg, Black Box)

Answer 20

UC, ulcerative proctitis. No. None.