Spring Quiz 1

Question 1

Atorvastatin (Brand, Class, MOA)

Answer 1

Lipitor. HMG-CoA Inhibitor which causes px production of mevalonic acid; increases LDL receptors and LDL catabolism; decreases levels of high-sensitivity C-reactive protein (hsCRP).

Question 2

Atorvastatin (Indication, BBW, Preg)

Answer 2

HLD. No. X.

Question 3

Niacin (Brand, Class, MOA)

Answer 3

Niaspan, Slo-Niacin. Antilipemic agent. Niacin is bioconverted to NAD+/NADH which are coenzymes for tissue metabolism, lipid metabolism, and glycogenolysis

Question 4

Niacin (Indication, BBW, Preg)

Answer 4

HLD. No. No.

Question 5

Ezetimibe, Simvastatin/Ezetimibe (Brand, Class, MOA)

Answer 5

Zetia. Antilipemic agent/HMG CoA R-I. Inhibits absorption of chol at the brush border of the SI via NPC1L1. leads to less delivery of chol to the liver, less hepatic chol stores & an more CL of chol from blood; decreases TC/LDL/ApoB/TG, increases HDL

Question 6

Fenofibrate (Brand, Class, MOA)

Answer 6

Tricor. Antilipemic agent, fabric acid. P-par agonist that down reg apoCIII (inhibitor of LPL).

Question 7

Ezetimibe, Simvastatin/Ezetimibe (Indication, BBW, Preg)

Answer 7

HLD. No. No.

Question 8

Fenofibrate (Indication, BBW, Preg)

Answer 8

HLD. No. No.

Question 9

Furosemide (Brand, Class, MOA)

Answer 9

Lasix. Loop diuretic. Inhibits reabsorption of Na and Cl in the ascending loop of Henle and distal renal tubule, interfering with the Cl-binding cotransport sys, thus causing increased excretion of water, Na, Cl, Mg, and Ca

Question 10

Furosemide (Indication, BBW, Preg)

Answer 10

HTN, edema. Fluid/electrolyte loss. No.

Question 11

Hydrochlorothiazide (HCTZ) (Brand, Class, MOA)

Answer 11

Microzide. Thiazide diuretic. Inhibits Na reabsorption in the distal tubules causing increased excretion of Na & water as well as K+ & H+

Question 12

HCTZ (Indication, BBW, Preg)

Answer 12

HTN, edema. No. No.

Question 13

Spironolactone (Brand, Class, MOA)

Answer 13

Aldactone. AntiHTN agent, K+ sparing diuretic, mineralicorticoid R antagonist. Competes with aldosterone for R sites in the distal renal tubules, increasing NaCl & water excretion while conserving K+ and H+; may block the effect of aldosterone on arteriolar smooth muscle as well

Question 14

Spironolactone (Indication, BBW, Preg)

Answer 14

HTN, edema, primary hyperaldosteronism, hypokalemia, CHF.. Tumorigenic. No.

Question 15

Clonidine (Brand, Class, MOA)

Answer 15

Catapres, Catapres-TTS. Alpha-2 adrenergic agonist. Stimulates alpha2-R in the brain stem, thus activating an inhibitory neuron, resulting in reduced symp outflow from CNS, producing a decrease in peripheral resistance, renal vascular resistance, HR, and BP

Question 16

Clonidine (Indication, BBW, Preg)

Answer 16

HTN. 500 mcg/mL should be diluted. No.

Question 17

Omega-3PUFAs (Brand, Class, MOA)

Answer 17

Lovaza. Antilipemic agent. Possible mechanisms include inhibition of acyl CoA:1,2 diacylglycerol acyltransferase, increased hepatic mitochondrial and peroxisomal beta-oxidation, a reduction in the hepatic synthesis of triglycerides, or an increase in plasma lipoprotein lipase activity.

Question 18

Omega-3PUFAs (Indication, BBW, Preg)

Answer 18

HLD. No. No.