Quiz 1 Flashcards
Prednisone (brand, class, MOA)
Sterapred. Systemic corticosteroid. Decreases inflammation by suppressing polymorphonuclear leukocyte migration and reversal of increased capillary permeability; reduces lymphatic system activity
Black box warnings: N/A
Prednisone (preg x, indications)
No. Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis/erythroderma; contact dermatitis; atopic dermatitis (AD); mycosis fungoides; severe psoriasis (various dermatological conditions)
Methylprednisolone (brand, class, MOA)
Solu-Medrol; Medrol. Systemic corticosteroid. Decreases inflammation by suppressing polymorphonuclear leukocyte migration and reversal of increased capillary permeability.
Methylprednisolone (preg x, indications)
No. Pemphigus; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; bullous dermatitis herpetiformis; severe seborrheic dermatitis; severe psoriasis; mycosis fungoide (various dermatological conditions).
Triamcinolone (brand, class, MOA)
Kenalog. Topical corticosteroid. Decreases inflammation by suppressing polymorphonuclear leukocyte migration and reversal of increased capillary permeability.
Triamcinolone (preg x, indications)
No. Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, or severe erythema multiforme (Stevens-Johnson syndrome). Oral inflammatory lesions and ulcers, atopic dermatitis.
Etanercept (brand, class, MOA)
Enbrel. DMARD; TNF-alpha blocker. Binds TNF-alpha and blocks its interaction with cell surface receptors. TNF-alpha plays an important role in inflammation.
Etanercept (preg x, indications)
No. Plaque psoriasis, psoriatic arthritis, moderate to severe psoriasis, RA.
Infliximab (brand, class, MOA)
Remicade.
DMARD; TNF-alpha blocker.
Binds TNF-alpha and blocks its interaction with cell surface receptors. TNF-alpha plays an important role in inflammation.
Infliximab (preg x, indications)
No. Plaque psoriasis, psoriatic arthritis, RA.
Adalimumab (brand, class, MOA)
Humira.
DMARD, TNF-alpha blocker.
Binds TNF-alpha and blocks its interaction with cell surface receptors. TNF-alpha plays an important role in inflammation.
Adalimumab (preg x, indications)
No. Plaque psoriasis, psoriatic arthritis.
Ustekinumab (brand, class, MOA)
Stelara. Antipsoriatic agent; IL-12; 23 inhibitor; mAb.
Binds to and interferes with the pro-inflammatory cytokines, IL-12 and IL-23, which are responsible for NK cell activation and CD4+ T-cell differentiation/activation.
Ustekinumab (preg x, indications)
No. Plaque psoriasis, psoriatic arthritis.
Black Box Warnings
Infections, malignancies, TB. Adalimumab, infliximab, etanercept.
