SPINE - degenerative

Question 1

What is the frequent findings during neurological examination in dogs with degenerative myelopathy?

Answer 1

Depressed patellar reflex with normal tonus to hypertonia and no muscular atrophy.
->Loss of sensory component of the reflex arc

Question 2

Which is the only spared funiculus in Afghan Hound Myelinolysis?

Answer 2

Fasciculus proprius

Onset: 3-13 months
Start midthoracic and progress cranially and caudally with recumbency by 14-21d

Question 3

CSF phosphorylated neurofilament heavy is not a reliable diagnostic marker of degenerative myelopathy: true or false?

Answer 3

False

Compared with old control dogs, median CSF pNF-H concentration was increased in all stages of DM. CSF pNF-H concentration >20.25ng/mL was 80.4% sensitive and 93.6% specific for DM.

No differences in serum pNF-H concentration were found between control and DM-affected dogs.

Question 4

In which dog breed the SOD mutation has a different locus than usually reported?

Answer 4

SOD1:c.118 A/G
Bermese Montain dog:
SOD1:c52 T

Question 5

Leucoencephalomyelopathy in Rottweiller & Leonberg: gene, onset, type of lesions, localisation of lesions

Answer 5

NAPEPLD (AR)
1-2 years
Demyelinisation
Cervical spinal cord (lateral funiculi, occasionally dorsal funiculi), brainstem, optic tract and nerves, cerebellum