BRAIN - Neoplasia Flashcards
Which tumor of the cranial fossa can be suspected in a young dog?
Germ cell tumors
What are the most common clinical signs associated with pituitary apoplexy in dogs?
Galli, 2022:
Behavioural abnormalities (11/19)
Obtundation (7/19)
Vestibular syndrome (7/19)
Epileptic seizures (6/19)
Woelfel, 2023:
Gait or posture changes (85%)
Mentation changes (69%)
Cranial neuropathies (65%)
GI dysfunction (54%)
Cervical/head hyperpathia (46%)
Hyperthermia (31%)
What is the influence of macroadenoma on vital parameters? Which cut-offs can be used to differentiate from microadenoma?
Lower body temperature (cut-off: 38,3°C)
Lower heart rate (cut-off: 84 bpm)
Benchekroun, 2017
In glioma, lesions tend to be hyperintense on ADC maps while infarcts tend to be hypointense: true or false?
True
What are the 2 most tumor types associated with CSF drop metastasis?
Choroid plexus carcinoma
Oligodendroglioma
Which breed is not predisposed to glioma?
English Bulldog
Pug
Boxer
French Bulldog
Boston terrier
Pug
Succint prednisolone tapering (40d vs 100) after radiation therapy has a significative effect on
1/ Rates at which corticosteroids had to be reinstituted later
2/ Adverse effect rates
No
What are the 2 most common cause of VPS obstruction?
Choroid plexus
Glial tissue
Germ cell neoplasm are commonly found: where, when, which breed?
Middle cranial fossa
Young (6m-3y)
Doberman
Breeds overrepresented for CNS histiocytic sarcoma?
Burmese Mountain Dog
Golden Retriever
Rottweiler (disseminated exclusively)
Corgi Welsh terrier (primary > disseminated)
**Shetland Sheepdogs (primary **> disseminated)
Labrador Retriever?
TNCC and protein: primary»_space;> disseminated
In all groups: increased neutrophil to lymphocyte ratio
Prevalence of brain tumors: primary (2%), secondary (3%)
What are the most common perioperative and postoperative complications following craniotomy in dogs and cats?
Perioperative complications
Hypotension (23%)
Anemia (16%)
Postoperative complications
Neurologic deficits
Seizures
Anemia
Aspiration pneumonia
What are the 1H-MRS hallmarks of neoplasia?
Increased NAA, Cr, Glx
Decreased Cho (choline)
In intravascular lymphoma in dogs, contrast enhancement is seen in which of the following: ischemic areas, parenchymal lesions and/or meninges?
Parenchymal lesions and meninges
Differential for supprasellar neoplasia in dog.
Macroadenoma
Meningioma
Lymphoma
Granular cell tumor
Gliomatosis cerebri
Craniopharyngioma
Germ cell tumor
Metastasis
True or false? In dogs with pituitary macroadenoma that undergo radiation therapy, the presence of pituitary dependant hypercortisolism is a negative prognostic indicator.
False
“No statistical difference in survival was identified between the PDH and non-PDH groups, and longer survival was associated with higher Gy delivered.”
