MNP - Ears

Question 1

Genes in the hearing loss and congenital vestibular syndrome in doberman ? ​

Answer 1

PTPRQ (MYO7A)
protein tyrosin phosphatase
neuroepitelial, abnormal/abs otoconia

onset 3 wo, unilat

Question 2

The hereditary deafness of cats with white coat and blue eyes is due to

Answer 2

loss of hair cells following the degeneration of the stria vascularis in the absence of melanocyte

Question 3

pure breed white cats with congenital sensorineural deafness: prevalence, uni vs bilat more fq ?

Answer 3

a prevalence of 30.3% (15.9% bilateral, 14.4% unilateral)

Question 4

Ototoxicity: choose the CORRECT

1. Cochlear and vestibular ototoxicity from aminoglycosides is usually irreversible
2. Toxicity from aminoglycosides may happen long after cessation of treatment
3. Diuretic ototoxicity is usually temporary.
4. All of the above

Answer 4

4

Question 5

White cats with blue irises are not more at risk to have congenital sensorineural deafness: true or false?

Answer 5

False

Kittens with at least 1 blue iris were 3.2 times more likely to have CSD than kittens without blue irises.

Question 6

What are the 3 breeds associated with deafness in white cats?

Answer 6

Norwegian Forest (44%)
Maine Coon (44%)
Turkish Vankedisi (47%)

Congenital sensorineural deafness was diagnosed only in solid white kittens, with a prevalence of 30.3%.

Question 7

What are the BAER findings in hypothyroidism-associated central vestibular disease?

Answer 7

Segmental demyelination in brainstem
Longer latencies waves II to V
Longer iPL I-V

Question 8

deafness in white devon rex:
prevalence
uni or bilat
assoc with blue iris

Answer 8

10%
equally often uni/bilat
no

Question 9

hearing range dog/cat/human

Answer 9

dog 67Hz-45kHz
cat 45Hz-64kHz
human 64Hz-23kHz

Question 10

2 types of periferal deafness

Answer 10

sensorioneural (albinotic/abiotrophic)
conductive

Question 11

genes associated with deafness

Answer 11

EDNRB (Am Paint, Pinto)
MITF (Piebald)
KIT (Whitte spoting in cat + cattle, pig)
PMEL (Merle)
CDH23 (Pointer)
TRPMZ1
TYR
USP31, RBBP (Border C, late onset)

Question 12

prevalence of deafness in dalamtian, dogo argentino, australian cattle, bull terrier, english setter

Answer 12

dalmatian 17% (old study 28%) (one or both, blue iris, pigmented patch head)
dogo argentino 26% (whithout patch ++)
aust cattle 15%
bull terrier 12%
english setter 4-8% (female&raquo_space;)

Question 13

latency in foals/adult

Answer 13

foal/adult
1: 1/2.2
2: ?/3.6
3: 2.3/?
5: 4/5.4

neurologic disease ->assymetry

Question 14

genetic deafness in horse

Answer 14

Am Paint white foal syndrome
EDNRB (role in neural crest devt)

Question 15

BAER in horses with THO

Answer 15

prolonged latency peak I-V, normal interpeak interval

Question 16

most common cause unilat deaf horse

Answer 16

THO>otitis med>multifocal brain

Question 17

culture middle ear in brachyceph

Answer 17

80% no bacterial growth, maj Staph pseudintermedus
cyo neutro and macrophage

Question 18

FLAIR int ear in cat with OMI

Answer 18

lower FLAIR supp, increased CSF cell count

Question 19

only mol with efficacity against nausea in vest disease

Answer 19

ondansetron (dim arginine vasopressine)

Question 20

Name of air in int ear

Answer 20

penumolabyrinth, associated with OMI (trauma in human)

Question 21

most common bact in cat with OMI + intracranial comp

Answer 21

pasteurella multilocida

Question 22

cat breed with neuroepitelial deafness (degen hair cells)

Answer 22

Burmese
Siamese

Question 23

cat breed with maj congenit sensorineural deafness

Answer 23

Norwegian forest
Main Coon
Turkish Angora

locus for S near KIT gene + W gene domint

30% preval in purebreed white kitten
associated with at least one blue iris

Question 24

ototoxic mol

Answer 24

aminoglycoside: usually irrev, iron chelation foloweed by free radical formation, vesti + audit

cisplatine, carboplatin: irreversible, no vestib. prod oxyg react sp

furosemide (loop diuret)

salicylates and quinine: assoc with tinnitus, reversible

chlorexidine