Sodium Valproate Flashcards
1
Q
What drug class is Sodium Valproate?
A
Anti-epileptic drug
2
Q
What are the common indications for Sodium Valproate?
A
- Epilepsy - 1st line for generalised epilepsies
* Mania (mood stabiliser)
3
Q
What is the mechanism of action of Sodium Valproate?
A
GABAa effects and sodium channel blocker
4
Q
What are the common adverse reactions of Sodium Valproate?
A
- Liver failure
- Pancreatitis
- Lethargy
- Tiredness/drowsiness
- Nausea and vomiting
- Mood changes
- Osteoporosis
Risks of congenital malformations if women gets pregnant
5
Q
What are the common drug-drug interactions of Sodium Valproate?
A
- It’s a CYP inhibitor - so can increase the plasma conc of some drugs e.g. other AEDs
- Patients on AEDs and warfarin will need close monitoring (valproate is an inhibitor or CYP450s that metabolise warfarin)
