Fluticasone Flashcards
1
Q
What drug class is Fluticasone?
A
Inhaled corticosteroid
2
Q
What are the common indications of Fluticasone?
A
Asthmatics (a preventer inhaler when the reliever is not enough)
3
Q
What is the mechanism of action of Fluticasone?
A
Activates cytoplasmic receptors, activated receptor passes into nucleus and modifies transcription
Reduced mucosal inflammation, widens airways and reduced mucous - reduces symptoms, exacerbations and death
4
Q
What are the common adverse reactions of Fluticasone?
A
Local immunosuppression - candidiasis, hoarse voice
Have poor oral bioavailability so ADRs are limited to the respiratory system
5
Q
What are the common drug-drug interactions of Fluticasone?
A
Very few
* other ICS?
