Apixaban Flashcards
1
Q
What drug class is Apixaban?
A
A direct oral anticoagulant (direct Xa)
2
Q
What are the common indications for Apixaban?
A
- VTE prophylaxis
- DVT treatment and prophylaxis
- Stroke/systemic embolism prophylaxis
(Instead of Warfarin)
3
Q
What is the mechanism of action of Apixaban?
A
Inhibits free Xa and Xa bound to ATIII
4
Q
What are the common adverse reactions of Apixaban?
A
- Bleeding (esp. GI)
5
Q
What are the common drug-drug interactions of Apixaban?
A
- Affected by CYP inhibitors and inducers (less so than Warfarin) - plasma conc increased by macrolides, plasma conc decreased by carbamazepine, phenytoin and barbiturates
