Co-Amoxiclav Flashcards
1
Q
What drug class is Co-Amoxiclav?
A
A penicillin (beta-lactam)
2
Q
What are the common indications for Co-Amoxiclav?
A
Used when amoxicillin alone isn’t appropriate (with beta-lactamase producing strains)
- Bacterial meningitis
- Bone/joint infections
- Pneumonia
- Otitis media
- Skin and soft tissue infections
- UTIs and STIs
3
Q
What is the mechanism of action of Co-Amoxiclav?
A
Amoxicillin interferes with the synthesis of the bacterial cell wall peptidoglycan (bactericidal)
The clavulanic acid used to overcome beta-lactamases
4
Q
What are common adverse reactions of Co-Amoxiclav?
A
- Diarrhoea
- Nausea and vomiting
- Hypersensitivity
- Skin reactions
- Thrombocytopenia
5
Q
What are common drug-drug interactions of Co-Amoxiclav
A
General for penicillins - penicillins increase the effects of warfarin by inhibiting bacteria that synthesise vitamin K in the gut
