Indapamide

Question 1

What class of drugs is Indapamide?

Answer 1

A thiazide-like diuretic

Question 2

What are the common indications for Indapamide?

Answer 2

• Hypertension

Question 3

What is the mechanism of action of Indapamide?

Answer 3

Inhibits Na+/Cl- cotransport in the DCT (so less Na+ and water reabsorption)

Shouldn’t take in the afternoon (take in the morning) to avoid waking to go to the toilet

Question 4

What are some important adverse drug reactions of Indapamide?

Answer 4

• Hypokalaemia
• Hypernatraemia
• Hyperuricaemia (gout)
• arrhythmia
• increased glucose (esp when taken with beta-blockers)
• increased cholesterol and triglyceride

HyperGLUC

Question 5

What are some important drug-drug interactions of Indapamide?

Answer 5

• NSAIDs

* drugs that decrease potassium e.g. loop diuretics - need electrolyte monitoring