Salbutamol

Question 1

What class is Salbutamol?

Answer 1

A short acting, fast beta-2 agonist

Question 2

What are the common indications for Salbutamol

Answer 2

• For short term, fast symptom relief of asthma

* To prevent bronchoconstriction prior to exercise

Question 3

What is the mechanism of action of Salbutamol?

Answer 3

Reverses bronchoconstriction (via beta-2 receptors in airway smooth muscle)
Also increases mucus clearance by cilia action

Beta-2 agonist binds, AC activated, increased cAMP, increased PKA activation, bronchial smooth muscle relaxation

If used to regularly, effects of drug could decrease

Question 4

What are the common adverse reactions of Salbutamol?

Answer 4

• Adrenergic symptoms - tachycardia, palpitations, anxiety and tremor
• Increased glycogenolysis
• Increased renin release
• SVT risk (due to increase SAN activity so increased HR and decreased refractory period at AVN)

Question 5

What are the common drug-drug interactions of Salbutamol?

Answer 5

• Beta-blockers - reduces effects of beta-2 agonists