Celecoxib

Question 1

What drug class is Celecoxib?

Answer 1

Selective COX-2 inhibitor (NSAID)

Question 2

What are the common indications for Celecoxib?

Answer 2

• Osteoarthritis

* RA

Question 3

What is the mechanism of action of Celecoxib?

Answer 3

Inhibits COX-2 - inhibits PGI2 and PGE2 production
However unlike COX-1 inhibitors, it doesn’t inhibit thromboxane A2 production

(Etorcoxib is more selective than Celecoxib)

Question 4

What are the common adverse reactions of Celecoxib?

Answer 4

• Renal ADRs (Reduced GFR and reduced renal blood flow) - therapeutic doses, less adverse reactions
• less GI ADRs as more selective (dyspepsia, GI bleeding, nausea, peptic ulceration)
• Risk of MI

Question 5

What are the common drug-drug interactions of Celecoxib?

Answer 5

• Aspirin
• Glucocorticoid steroids
• Anticoagulants (give with PPI)
• ACEi
• ARBs
• Diuretics