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Pharmacology > Smooth Muscle Drugs > Flashcards

Smooth Muscle Drugs Flashcards

1
Q

DOC for acute migranr

A
  1. Sumatriptan : 5HT 1D Receptor Agonist
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2
Q

DOC for chemotherapy induced vomiting?

A

Ondansetron: 5-HT3 Receptor Antagonist

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3
Q

Use of H-1 receptor antagonist?

A
  1. Hay fever
  2. Urticaria
  3. Motion sickness
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4
Q

5-HT 2 receptor antagonist used for postpartum bleeding

A

Ergonovine

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5
Q

5-HT4 partial agonist used for IBS with component constipation

A

Tegaserod

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6
Q

Prokinetic agent that acts as selective 5HT4 agonist

A

Mosapride

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7
Q

Triple response of Lewis

A

Wheal, Flush, Flare

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8
Q

Use of Cyproheptadine

A

Serotonin syndrome

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9
Q

Avoid giving with dextromethorphan to avoid serotonin syndrome?

A

Hydralazine

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10
Q

H2 blocker known to cause gynecomastia?

A

Cimetidine

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11
Q

H3 antagonist used for vertigo ?

A

Betahistine

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12
Q

Teratogenic effect of misoprostol?

A

Moebius sequence

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13
Q

Common adverse effects of misoprostol?

A

Abdominal pain & Diarrhea

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14
Q

PGE1 analog used in the maintenance of PDA?

A

Alprostadil

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15
Q

PGE2 analog used for induction of labor or cervical ripening?

A

Dinoprostone (Dinalawa)

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16
Q

Drig used for glaucoma that may alter the color of the Iris?

A

Latanoprost

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17
Q

Use of the PGI2 analog Epoprostenol?

A
  1. Pulmonary hypertension
  2. Reduces platelet aggregation in dialysis machines
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18
Q

MOA of Glycopyrronium?

A

LAMA ( anti-muscarinic)
Monotherapy as maintenance for COPD

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19
Q

PDE5 inhibitor used in erectile dysfunction?

A

Tadalafil

20
Q

PDE inhibitor & Adenosine receptor antagonist used for intermittent claudication?

A

Pentoxyfylline

21
Q

Enzyme inhibited by corticosteroids?

A

Phospholipase A2

22
Q

5-LOX inhibitor?

A

Zileuton

23
Q

Mast cell stabilizers

A

Cromolyn. , Nedocromil, Lodoxamide

24
Q

MOA and use of Omalizumab?

A

Anti-IgE
For prophylaxis of severe, refractory asthma not responsive to other drugs

25
Q

General MOA of mucolytics?

A

Reduce disulfide bridges that bind glycoproteins to other proteins such as albumin.

26
Q

Drug that supresses coughing reflex?

A

Dextromethorphan

27
Q

MOA of Butamirate citrate?

A

Act through receptors in the brainstem to inhibit cough

28
Q

MOA of lagundi?

A

Inhibits PDE III & Inhibits Ca2+ entry , bronchodilator

29
Q

Adverse effects of H2 receptor antagonist?

A

Diarrhea
Headache
Fatigue
Myalgias
Constipation

30
Q

Inhalational anesthetics?

A

Nitrous oxide
Halothane
Desflurane
Enflurane
Isoflurane
Sevoflurane
Methoxyflurane

31
Q

How does suxamethonium chloride cause muscle paralysis?

A

Blocking of acetylcholine

32
Q

Suxamethonium is normally metabolized by this enzyme?

A

Butyrylcholinesterase

33
Q

Dirst line for acute exacerbation of asthma?

A

Salbutamol

34
Q

Why is corticosteroid used in bronchial asthma?

A
  1. Decrease airway hyper responsiveness
  2. Fewer asthma exacerbation
  3. Potentiate action of Beta adrenergic agonist
35
Q

Long acting beta 2 agonist preferred in the long term treatment of asthma?

A

Salmeterol
Formoterol

36
Q

Act by blocking the effects of slow reacting substance of anaphylaxis?

A

Montelukast

37
Q

Drug for asthma that is used less due to its adverse effects?

A

Theophylline

38
Q

Third generation antihistamines?

A
  1. Fexofenadine
  2. Bilastine
  3. Levocetirizine
39
Q

Drug that blocks mast cell degranulation preventing release of histamine in asthma exacerbation?

A

Ketotifen

40
Q

Characteristics of Theophylline?

A

Narrow therapeutic window
Metabolized by CYP450

41
Q

Drugs that achieve relaxation of smooth muscle in bronchial asthma

A

Ipratropium bromide
Terbutaline
Theophylline

42
Q

In addition to the effect of tramadol on pain by affecting opioid receptors , its also affects which neurotransmitters?

A

Serotonin
NE
Dopamine

43
Q

Notorious side effect of Fentanyl?

A

Respiratory depression

44
Q

Mimics uterotonic effect of Oxytocin on uterus?

A

Carbetocin

45
Q

MOA of Oxycodone?

A

Agonist at Mu and Kappa receptors

46
Q

Reasons of withdrawing Rofecoxib ( Cox-2 Inh) from the market?

A

Increased incidence of Myocardial Infarction

Pharmacology (12 decks)

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