Smooth Muscle Drugs

Question 1

DOC for acute migranr

Answer 1

1. Sumatriptan : 5HT 1D Receptor Agonist

Question 2

DOC for chemotherapy induced vomiting?

Answer 2

Ondansetron: 5-HT3 Receptor Antagonist

Question 3

Use of H-1 receptor antagonist?

Answer 3

1. Hay fever
2. Urticaria
3. Motion sickness

Question 4

5-HT 2 receptor antagonist used for postpartum bleeding

Answer 4

Ergonovine

Question 5

5-HT4 partial agonist used for IBS with component constipation

Answer 5

Tegaserod

Question 6

Prokinetic agent that acts as selective 5HT4 agonist

Answer 6

Mosapride

Question 7

Triple response of Lewis

Answer 7

Wheal, Flush, Flare

Question 8

Use of Cyproheptadine

Answer 8

Serotonin syndrome

Question 9

Avoid giving with dextromethorphan to avoid serotonin syndrome?

Answer 9

Hydralazine

Question 10

H2 blocker known to cause gynecomastia?

Answer 10

Cimetidine

Question 11

H3 antagonist used for vertigo ?

Answer 11

Betahistine

Question 12

Teratogenic effect of misoprostol?

Answer 12

Moebius sequence

Question 13

Common adverse effects of misoprostol?

Answer 13

Abdominal pain & Diarrhea

Question 14

PGE1 analog used in the maintenance of PDA?

Answer 14

Alprostadil

Question 15

PGE2 analog used for induction of labor or cervical ripening?

Answer 15

Dinoprostone (Dinalawa)

Question 16

Drig used for glaucoma that may alter the color of the Iris?

Answer 16

Latanoprost

Question 17

Use of the PGI2 analog Epoprostenol?

Answer 17

1. Pulmonary hypertension
2. Reduces platelet aggregation in dialysis machines

Question 18

MOA of Glycopyrronium?

Answer 18

LAMA ( anti-muscarinic)
Monotherapy as maintenance for COPD

Question 19

PDE5 inhibitor used in erectile dysfunction?

Answer 19

Tadalafil

Question 20

PDE inhibitor & Adenosine receptor antagonist used for intermittent claudication?

Answer 20

Pentoxyfylline

Question 21

Enzyme inhibited by corticosteroids?

Answer 21

Phospholipase A2

Question 22

5-LOX inhibitor?

Answer 22

Zileuton

Question 23

Mast cell stabilizers

Answer 23

Cromolyn. , Nedocromil, Lodoxamide

Question 24

MOA and use of Omalizumab?

Answer 24

Anti-IgE
For prophylaxis of severe, refractory asthma not responsive to other drugs

Question 25

General MOA of mucolytics?

Answer 25

Reduce disulfide bridges that bind glycoproteins to other proteins such as albumin.

Question 26

Drug that supresses coughing reflex?

Answer 26

Dextromethorphan

Question 27

MOA of Butamirate citrate?

Answer 27

Act through receptors in the brainstem to inhibit cough

Question 28

MOA of lagundi?

Answer 28

Inhibits PDE III & Inhibits Ca2+ entry , bronchodilator

Question 29

Adverse effects of H2 receptor antagonist?

Answer 29

Diarrhea Headache Fatigue Myalgias Constipation

Question 30

Inhalational anesthetics?

Answer 30

Nitrous oxide Halothane Desflurane Enflurane Isoflurane Sevoflurane Methoxyflurane

Question 31

How does suxamethonium chloride cause muscle paralysis?

Answer 31

Blocking of acetylcholine

Question 32

Suxamethonium is normally metabolized by this enzyme?

Answer 32

Butyrylcholinesterase

Question 33

Dirst line for acute exacerbation of asthma?

Answer 33

Salbutamol

Question 34

Why is corticosteroid used in bronchial asthma?

Answer 34

1. Decrease airway hyper responsiveness 2. Fewer asthma exacerbation 3. Potentiate action of Beta adrenergic agonist

Question 35

Long acting beta 2 agonist preferred in the long term treatment of asthma?

Answer 35

Salmeterol Formoterol

Question 36

Act by blocking the effects of slow reacting substance of anaphylaxis?

Answer 36

Montelukast

Question 37

Drug for asthma that is used less due to its adverse effects?

Answer 37

Theophylline

Question 38

Third generation antihistamines?

Answer 38

1. Fexofenadine 2. Bilastine 3. Levocetirizine

Question 39

Drug that blocks mast cell degranulation preventing release of histamine in asthma exacerbation?

Answer 39

Ketotifen

Question 40

Characteristics of Theophylline?

Answer 40

Narrow therapeutic window Metabolized by CYP450

Question 41

Drugs that achieve relaxation of smooth muscle in bronchial asthma

Answer 41

Ipratropium bromide Terbutaline Theophylline

Question 42

In addition to the effect of tramadol on pain by affecting opioid receptors , its also affects which neurotransmitters?

Answer 42

Serotonin NE Dopamine

Question 43

Notorious side effect of Fentanyl?

Answer 43

Respiratory depression

Question 44

Mimics uterotonic effect of Oxytocin on uterus?

Answer 44

Carbetocin

Question 45

MOA of Oxycodone?

Answer 45

Agonist at Mu and Kappa receptors

Question 46

Reasons of withdrawing Rofecoxib ( Cox-2 Inh) from the market?

Answer 46

Increased incidence of Myocardial Infarction