Antibiotics

Question 1

DOC for Syphilis

Answer 1

Penicillin G

Question 2

Methicillin was withdrawn due to the incidence of?

Answer 2

Interstitial nephritis

Question 3

Anti-staphylococcal penicillins?

Answer 3

1. Methicillin
2. Nafcillin
3. Oxacillin
4. Cloxacillin
5. Dicloxacillin

Question 4

Azlocillin and Mezlocillin were withdrawn due to the incidence of ?

Answer 4

Blood dyscrasia : any condition that affects the blood, bone marrow, or lymph tissue.

Question 5

Extended spectrum penicillins

Answer 5

Ampicillin
Amoxicillin

Question 6

Piperacillin , Ticarcillin, Carbenicillin are for infections due to?

Answer 6

Pseudomonas
Enterobacter
Klebsiella

Question 7

Spectrum of activity of 1st gen cephalosporins

Answer 7

“PEcK FIRST “
Proteus mirabilis
Escherichia coli
Klebsiella pneumoniae

Question 8

Spectrum of activity of 2ng gen cephalosporins?

Answer 8

“HEN PEcKS”
H influenzae
Enterobacter aerogenes
Neisseria spp.
Proteus mirabilis
Escherichia coli
Klebsiella pneumonia
Serratia marcescens

Question 9

Cephalosporins causing a disulfiram-like reaction?

Answer 9

“ I MET a MAN who FOUGHT for TONS of MONEY and DIED SOON (Disulfiram)
Cefometazole
Cefamandole
Cefotetan
Cefoperazone

Question 10

Anti-psedomonal cephalosporins?

Answer 10

Ceftazidime
Cefepime
Cefoperazone

Question 11

Antipsedomonal Cephalosporins

Answer 11

Ceftazidime
Cefepime
Cefoperazone

Question 12

All third gen cephalosporins penetrate the BBB except?

Answer 12

Cefoperazone
Cefixime

Question 13

DOC for gonorrhea?

Answer 13

Ceftriaxone

Question 14

Effective drug for treatment of soft chancre / chancroid ?

Answer 14

Ceftriaxone

Question 15

Antibiotic that may be given for both proteus & pseudomonas?

Answer 15

Cefepime

Question 16

Empiric treatment for septic arthritis

Answer 16

Vancomycin

Question 17

Drugs may be given in the treatment of MRSA

Answer 17

Vancomycin
Ceftaroline
Linezolid
Clindamycin

Question 18

Cephalosporin used for MRSA infections

Answer 18

Ceftaroline

Question 19

Aztreonam uses

Answer 19

Infections resistant to btea-lactamases produced by gram negative rods, including Klebsiella, Pseudomonas, Serratia.

Question 20

Carbapenems are active against Pseudomonas and Acinetobacter except?

Answer 20

Ertapenem ( kasi ma Arte sya)

Question 21

Reversible inhibitor of Xanthine oxidase?

Answer 21

Febuxostat

Question 22

Irreversible inhibitor of Xanthine oxidase?

Answer 22

Allopurinol

Question 23

Empiric treatment considered for an adult patient with fever, joint pain, and restricted range of morion.

Answer 23

Vancomycin + Ceftriaxone

Question 24

Moa of Relebactam, Vabrobactam?

Answer 24

Carbapenamase inhibitors ( novel)

Question 25

Antibiotic causing Red Man Syndrome?

Answer 25

Vancomycin

Question 26

Antibiotic causing gray baby syndrome?

Answer 26

Chloramphenicol

Question 27

Bacitracin is reserved for topical use only due to?

Answer 27

Marked nephrotoxicity

Question 28

DOC for shigella infection?

Answer 28

Quinolones: first line Azithromycin

Question 29

Adverse effects associated with Streptomycin?

Answer 29

Nephrotoxicity Ototoxicity Neuromuscular blockage

Question 30

Protein synthesis inhibitors : 30s 50s

Answer 30

30s Tetracycline Aminoglycosides 50s Chloramphenicol Erythromycin Lincosamides Linezolid “buy AT 30s CELL at 50s”

Question 31

All bacterial protein synthesis inhibitors are bacteriostatic except?

Answer 31

Aminoglycosides Streptogramins Chloramphenicol ( to Neisseria, Hemophilus, Bacteroides, S. Pneumoniae)

Question 32

Antibiotic also used for SIADH

Answer 32

Demeclocycline

Question 33

The macrolide witha good pharmacokinetic profile and is neither an inhibitor or inducer.

Answer 33

Azithromycin

Question 34

Antibiotic also used for SIADH

Answer 34

Demeclocycline

Question 35

Azithromycin advantages over Erythromycin?

Answer 35

1. Longer duration of action 2. Higher volume of distribution in the body 3. No inhibition on CYP450

Question 36

Antibiotic that has activity against treponema, chlamydia and neisseria?

Answer 36

Doxycycline

Question 37

Antibiotics that most commonly cause pseudomembranous colitis

Answer 37

Clindamycin Ampicillin

Question 38

Treatment for pseudomembranous colitis?

Answer 38

Metronidazole Oral vancomycin Fidaxomycin

Question 39

DOC for community acquired MRSA

Answer 39

Clindamycin

Question 40

DOC for Hospital Acquired MRSA

Answer 40

Vancomycin

Question 41

Treatment for VRSA

Answer 41

Linezolid Quinupristin - Dalfopristin

Question 42

Most ototoxic aminoglycosides

Answer 42

Kanamycin Amikacyn “Toxic KA”

Question 43

Used for drug resistant gonorrhea?

Answer 43

Spectinomycin

Question 44

Combining a sulfonamide + trimethoprim produces what kind of drug interaction?

Answer 44

Synergism ( cidal together, static alone)

Question 45

DOC for toxoplasmosis?

Answer 45

Sulfadiazine - Pyremethamine

Question 46

MOA of Quinolones

Answer 46

Topoisomerase II (DNA gyrase ) inhibitors in gram negative . Topoisomerase IV inhibitors in gram-positive

Question 47

Quinolone with a high rate for development of resistance?

Answer 47

Nalidixic acid

Question 48

Most active quinolone against gram negative organism esp pseudomonas?

Answer 48

Ciprofloxacin

Question 49

Grepafloxacin was withdrawn due to the incidence of?

Answer 49

Cardiotoxicity/ Arrhythmia

Question 50

Gatifloxacin was withdrawn due to incidence of?

Answer 50

Diabetes mellitus ( Gatamis)

Question 51

Most hepatotoxic Anti-TB drugs?

Answer 51

Pyrazinamide and Ethambutol

Question 52

Anti-TB drugs need dose adjustment when GFR <30

Answer 52

Pyrazinamide

Question 53

Anti-TB drug that causes asymptomatichyperuricemia

Answer 53

Pyrazinamide

Question 54

Hepatoxicity of Anti-TB deugs?

Answer 54

Isoniazid < Rifampin < Pyrazinamide

Question 55

Responsible for tingling sensation of hands among TB medicatons

Answer 55

Isoniazid

Question 56

Ocular manifestation of toxicity associated with Ethambutol?

Answer 56

Red green color blindness

Question 57

Anti - TB drugs side effects?

Answer 57

Rifampicin: red orange body fluids Isoniazid: Hepatitis, neurotoxicity (B6) Ethambutol: visual disturbances

Question 58

Sterilizing agent used the first 2 months of TB treatment

Answer 58

Pyrazinamide

Question 59

Most active drug against M. leprae

Answer 59

Dapsone

Question 60

Moa of terbinafine

Answer 60

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase

Question 61

Moa of amphothericin B

Answer 61

Binds to ergosterol in fungal cell membranes, forming artificial pores

Question 62

Adverse effect associated with aminoglycosides?

Answer 62

Hypersensitivity Ototoxicity Neurotoxicity

Question 63

Combining amphotericin B and Aminoglycosides increases the risk for?

Answer 63

Nephrotoxicity

Question 64

Examples of Triazoles ?

Answer 64

Posaconazole Itraconazole Voriconazole Fluconazole “Pak, Impaktang Veki Forever”

Question 65

Drug used for influenza A only

Answer 65

Uncoating inhibitors Amantadine ( also for Parkinsons) Rimantadine

Question 66

DOC for uncomplicated chloroquine resistant P. falciparum

Answer 66

Artemether + Lumefantrine ( CoArtem)

Question 67

Side effects of the deug Quinine and Quinidine?

Answer 67

Blackwater fever, Cinchonism

Question 68

Luminal amebicides

Answer 68

Diloxanide furoate Iodoquinol Paromomycin “ take a DIP in the lumen”

Question 69

DOC for early West African sleeping sickness?

Answer 69

Pentamidine

Question 70

DOC for early West African sleeping sickness with CNS involvement ?

Answer 70

Eflornithine

Question 71

DOC for early East African sleeping sickness?

Answer 71

Suramin

Question 72

DOC for early East African sleeping sickness with CNS involvement ?

Answer 72

Melarsoprol

Question 73

DOC for trematodes and cestodes

Answer 73

Praziquantel

Question 74

DOC for Whipworm

Answer 74

Mebendazole ( Me bending a Whip)

Question 75

DOC of Strongyloides

Answer 75

Ivermectin “ Ivan is so Strong”

Question 76

Drugs that may result to a Mazzotti reaction?

Answer 76

Diethylcarbamazine , Ivermectin

Question 77

Treatment of chronic paronychia

Answer 77

Topical azole

Question 78

Antibiotic of choice for trichomoniasis

Answer 78

Metronidazole

Question 79

Treatment for beef tapeworm?

Answer 79

Praziquantel m Niclosamide

Question 80

Side effects of Metronidazole

Answer 80

GI irritation Metallic taste Dark urine Leukopenia Disulfiram reaction

Question 81

MOA of Albendazole?

Answer 81

Inhibits microtubule assembly

Question 82

Anthelmentics that can be used for strongyloidiasis?

Answer 82

Ivermectin Thiabendazole Albendazole

Question 83

Antifungal limited to topical preparation?

Answer 83

Ketoconazole

Question 84

Drug that can be used to treat pinworm?

Answer 84

Pyrantel pamoate Albendazole Mebendazole

Question 85

Anti-pseudomonal penicillin that may given alone, without a beta lactamase inhibitor?

Answer 85

Carbenicillin

Question 86

Drugs with anti-folate activity

Answer 86

Methotrexate Sulfa drugs Trimethoprim

Question 87

Treatment of infections with HPV

Answer 87

Trichloroacetic acid Podophyllin Imiquimod

Question 88

Virus susceptible to Acyclovir

Answer 88

Varicella zoster CMV infection HSV infection

Question 89

Drug of choice for Influenza

Answer 89

Oseltamivir

Question 90

Virus susceptible to Acyclovir?

Answer 90

Varicella zooster CMV infection HSV infection

Question 91

Treatment of choice for Acyclovir - resistant HSV infection and can be used as substitute for CMV retinitis

Answer 91

Foscarnet

Question 92

Treatment for pregnant patient at 25 wks AOG diagnosed with Lymphgranuloma venereum

Answer 92

Erythromycin

Question 93

Anti-fungal drug with good CSF penetration

Answer 93

Fluconazole